Novel stem cell approach promising for heart failure

Novel stem cell approach promising for heart failure
A new method for delivering stem cells to damaged heart muscle has shown early promise in treating severe heart failure, researchers report online July 27 in Stem Cells Translational Medicine.
(HealthDay)—A new method for delivering stem cells to damaged heart muscle has shown early promise in treating severe heart failure, researchers report online July 27 in Stem Cells Translational Medicine.

Amit Patel, M.D., director of cardiovascular regenerative medicine at the University of Utah in Salt Lake City, and colleagues recruited 60 patients with severe heart failure. They randomly assigned 48 to receive stem cell therapy along with their usual care, and 12 to stay with standard care only.

The appeared safe, with no adverse effects linked to the treatment itself, the researchers note. And after one year, the patients showed a modest improvement in ejection fraction. It's not clear yet whether those improvements could be meaningful, Patel told HealthDay. He added that larger clinical trials are underway to see whether the approach could be an option for advanced heart failure.

Patel's team used a novel technique to deliver stem cells to the heart. They took stem cells from patients' bone marrow and infused them into the heart through the coronary sinus. "Most other techniques have infused stem cells through the arteries," Patel explained. One obstacle, he said, is that people with heart failure generally have hardened, narrowed coronary arteries, and the infused "don't always go to where they should."


Explore further

Can 'off the shelf' stem cell therapy treat heart failure patients? UB researcher aims to find out

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2015 HealthDay. All rights reserved.

Citation: Novel stem cell approach promising for heart failure (2015, August 3) retrieved 24 June 2019 from https://medicalxpress.com/news/2015-08-stem-cell-approach-heart-failure.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
12 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more