Scientists move closer to curing common eye disorder

Scientists move closer to curing common eye disorder
Scientists move closer to curing common eye disorder

Scientists at the University of Manchester have successfully restored the sight of laboratory mice suffering from a common cause of blindness in people.

A team led by Rob Lucas, GSK Professor of Neuroscience, carried out the pioneering research which may help sufferers of , a group of inherited eye disorders.

The treatment works by expressing a light sensitive human protein called rod opsin into the undamaged cells of the retina, so that it will turn them into special cells called photoreceptors which enable sight.

It was trialled on mice who had inherited advanced and so were essentially blind.

The mice were able to distinguish flickering from steady light as well as spatial patterns and a 'natural movie' – an advance on attempts to combat the disorders using non-human proteins.

Retinitis Pigmentosa is a leading cause of blindness worldwide: 1.5 million people worldwide are thought to be currently affected.

Using a , says Professor Lucas, is as advantageous as it is less harmful and easy to produce.

Professor Lucas said: "We aim to find ways of restoring photosensitivity to the retina in conditions such as retinitis pigmentosa in which loss of rod and lead to blindness.

"The protein rod opsin seems to be relatively successful under normal office light conditions, with images presented using standard computer screens.

"Other researchers have also had some success using other sorts of light protein, but these generally require much brighter light beyond what we generally experience."

Professor Luca's paper was published in the journal Current Biology.


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More information: "Restoration of Vision with Ectopic Expression of Human Rod Opsin," Current Biology, Volume 25, Issue 16, 17 August 2015, Pages 2111-2122, ISSN 0960-9822, dx.doi.org/10.1016/j.cub.2015.07.029
Journal information: Current Biology

Citation: Scientists move closer to curing common eye disorder (2015, September 2) retrieved 16 May 2022 from https://medicalxpress.com/news/2015-09-scientists-closer-common-eye-disorder.html
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