Cell-free circulating mtDNA identifies Parkinson's disease
Angela Pyle, Ph.D., from the University of Newcastle Upon Tyne in the United Kingdom, and colleagues examined whether ccf-mtDNA was an early indicator of PD pathology. Fifty-six CSF samples from patients with PD were selected with 10 age-matched asymptomatic control CSF samples.
The researchers observed a significant reduction in ccf-mtDNA in PD cases versus controls, when analyzing two mtDNA targets: MTND1 and MTDN4 copy number. In receiver operating characteristic curve analysis, MTND1- and MTND4-calculated ccf-mtDNA strongly predicted PD status (area under curve, 0.81 and 0.84, respectively). There was no significant correlation for ccf-mtDNA with CSF-tau, -phosphorylated tau, and -α-synuclein.
"Given the severity of the reduction in CSF ccf-mtDNA in PD, and supported by both subsequent measurement and remarkably similar data observed in Alzheimer's Disease, we conclude that ccf-mtDNA is a viable biomarker for the early detection of neurodegenerative disease," the authors write.
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