Omega-3 fatty acids may play role in bipolar disorder

December 7, 2015

Omega-3 fatty acids may play role in bipolar disorder
(HealthDay)—There may be a link between levels of omega-3 fatty acids and bipolar disorder, according to a small study published in the November issue of Bipolar Disorders.

Researchers compared 27 people with and 31 people without the mental illness. The team determined plasma concentrations of five (PUFAs) (linoleic acid, arachidonic acid, alpha-linolenic acid [ALA], docosahexaenoic acid [DHA], and eicosapentaenoic acid [EPA]), two saturated fatty acids (palmitic acid and stearic acid) and two monounsaturated (palmitoleic acid and oleic acid) in esterified (E) and unesterified (UE) forms.

In exploratory comparison, the researchers found lower UE:E EPA in the bipolar disorder group than the healthy controls group (P < 0.0001), and, at follow-up in the bipolar disorder group, UE, E DHA:ALA, and UE EPA:ALA were lower (P < 0.002). The team also found that mania severity and suicidality were positively correlated with UE:E EPA ratio, and several plasma levels and ratios correlated with panic disorder and psychosis.

"Altered n-3 PUFA ratios could indicate changes in PUFA metabolism concurrent with symptom improvement," the authors write. "Our findings are consistent with preclinical and postmortem data and suggest testing interventions that increase n-3 and decrease n-6 dietary PUFA intake."

Explore further: Lower availability of omega-3 fatty acids associated with bipolar disorder

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lower availability of omega-3 fatty acids associated with bipolar disorder

November 25, 2015
People with bipolar disorder have lower levels of certain omega-3 fatty acids that cross the blood-brain barrier than people who do not, according to researchers from Penn State College of Medicine and the National Institutes ...

Nothing fishy about health benefits of plant-based omega-3 fatty acid

November 17, 2014
Increasing the amount of omega-3s in your diet, whether from fish or flax, will likely decrease your risk of getting heart disease, according to Penn State nutritionists.

Low ratio of n3:n6 fatty acids correlates with CAD progression

January 23, 2013
(HealthDay)—For statin-treated patients with coronary artery disease, decreases in the ratio of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) correlate with atherosclerosis progression, according to research published ...

Effects of n-3 PUFAs on insulin sensitivity unclear

April 14, 2015
(HealthDay)—Dietary n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), do not appear to have clinically meaningful effects on peripheral or hepatic insulin sensitivity ...

Diet can predict cognitive decline: EPA, DHA remain important nutrients

April 29, 2014
The importance of long-chain polyunsaturated fatty acids (PUFAs) to brain health has been demonstrated in multiple studies. To assess whether lower dietary intake of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), ...

Fish oil supplementation doesn't cut inflammatory markers

November 2, 2015
(HealthDay)—For healthy adults, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation does not reduce common markers of systemic inflammation, according to a study published online Oct. 26 in the Journal ...

Recommended for you

Researchers discover abundant source for neuronal cells

December 13, 2018
USC researchers seeking a way to study genetic activity associated with psychiatric disorders have discovered an abundant source of human cells—the nose.

New genetic clues to early-onset form of dementia

December 13, 2018
Unlike the more common Alzheimer's disease, frontotemporal dementia tends to afflict young people. It accounts for an estimated 20 percent of all cases of early-onset dementia. Patients with the illness typically begin to ...

Video game players frequently exposed to graphic content may see world differently

December 13, 2018
People who frequently play violent video games are more immune to disturbing images than non-players, a UNSW-led study into the phenomenon of emotion-induced blindness has shown.

How teens deal with stress may affect their blood pressure, immune system

December 13, 2018
Most teens get stressed out by their families from time to time, but whether they bottle those emotions up or put a positive spin on things may affect certain processes in the body, including blood pressure and how immune ...

How bullying affects the brain

December 12, 2018
New research from King's College London identifies a possible mechanism that shows how bullying may influence the structure of the adolescent brain, suggesting the effects of constantly being bullied are more than just psychological.

Length of eye blinks might act as conversational cue

December 12, 2018
Blinking may feel like an unconscious activity, but new research by Paul Hömke and colleagues at the Max Planck Institute for Psycholinguistics, suggests that humans unknowingly perceive eye blinks as nonverbal cues when ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.