Symptoms tend to vary by patient's age for two leading breast cancer drugs

breast cancer
Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia

A study of two leading breast cancer drugs has determined that the breast cancer symptoms women experience while taking those drugs—and the severity of those symptoms—tend to vary based on the patients' ages.

The findings could be an important step toward personalized medicine for women with , said Dr. Patricia Ganz, director of the UCLA Jonsson Comprehensive Cancer Center's Prevention and Control Research program and the study's first author.

The study examined data for 1,193 postmenopausal women with a type of breast cancer called ductal carcinoma in-situ. The women had undergone lumpectomy and radiotherapy and were enrolled in a phase 3 clinical trial evaluating the drugs anastrozole and tamoxifen. The clinical trial confirmed that both drugs were safe.

Ganz and her team assessed factors influencing the women's quality-of-life as well as specific physical symptoms, such as hot flashes, , and muscle and joint pain. The drugs tended to affect women differently, Ganz said: Those taking tamoxifen generally had more severe hot flashes, and those taking anastrozole reported more sever vaginal dryness and muscle and joint pains.

The researchers then compared the results for women who were 60 and older with those who were under 60 years old. Women in the younger group were more likely to have , weight problems, vaginal symptoms and gynecological than those in the older group. Symptoms such as depression and fatigue affected in both age groups similarly, and did not worsen while they were taking the drugs.

Ganz will present the findings Dec. 11 at the San Antonio Breast Cancer Symposium, and the study was published online today by the journal The Lancet.

The scientists analyzed data from before the trial, during the five years of treatment and 12 months after.

The phase 3 clinical trial, from which the UCLA researchers drew the data for their study, was conducted to determine whether anastrozole was superior to tamoxifen. Ganz also is a co-author of that research, which also was published today by The Lancet.

"Both of these drugs are excellent and can reduce the risk for ," Ganz said. "Physicians and patients need to use this information along with the main trial outcomes to choose the optimal treatment for each woman."

Journal information: The Lancet
Citation: Symptoms tend to vary by patient's age for two leading breast cancer drugs (2015, December 11) retrieved 28 March 2024 from https://medicalxpress.com/news/2015-12-symptoms-tend-vary-patient-age.html
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