Study explains how low testosterone raises diabetes risk

Study explains how low testosterone raises diabetes risk
Dr. Franck Mauvais-Jarvis, Price-Goldsmith professor in the Department of Medicine at Tulane University School of Medicine. Credit: Paula Burch-Celentano, Tulane University

Doctors have long known that men with low testosterone are at greater risk for developing type 2 diabetes. For the first time, researchers have identified how testosterone helps men regulate blood sugar by triggering key signaling mechanisms in islets, clusters of cells within the pancreas that produce insulin. The findings, co-authored by Tulane University researchers, are published in the journal Cell Metabolism.

The study could help identify new treatments for type 2 diabetes in the large number of men with low testosterone due to age or prostate cancer therapies.

"We have found the cause—and a potential treatment pathway—for type 2 diabetes in testosterone-deficient men," says senior author Dr. Franck Mauvais-Jarvis, Price-Goldsmith professor in the Department of Medicine at Tulane University School of Medicine. "Our study shows that testosterone is an anti-diabetic hormone in men. If we can modulate its action without side effects, it is a therapeutic avenue for type 2 diabetes."

Researchers used specially bred male mice with lacking the receptor to testosterone (the androgen receptor). They fed them a Western diet rich in fats and sugar and tested their response to glucose. The mice without all developed lower insulin secretion, leading to glucose intolerance compared with normal mice in the control group.

To better understand how testosterone interacted with insulin production within the pancreas, researchers administered testosterone and glucose directly to human islet cells treated with an androgen receptor inhibitor and islets cells harvested from mice without androgen receptors. In both cases the islet cells showed decreased compared to islet cells whose receptor to testosterone was not inhibited or missing.

Further experiments in cultured mouse and human showed the insulin-producing effect of testosterone could be abolished by inhibiting glucagon-like peptide-1 (GLP-1), a hormone the body produces after a meal. The study suggests that amplifies the islet impact of the hormone, which is currently used as a diabetes treatment.


Explore further

New procedure could improve success rate of cell transplant to cure type 1 diabetes

Journal information: Cell Metabolism

Provided by Tulane University
Citation: Study explains how low testosterone raises diabetes risk (2016, April 28) retrieved 26 June 2019 from https://medicalxpress.com/news/2016-04-testosterone-diabetes.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
13 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more