Neuroscientists discover previously unknown function of cannabinoid receptor

The cannabinoid type 2 receptor - also called "CB2 receptor" - is a special membrane protein. Its function is to receive chemical signals that control cellular activity. "Until now, this receptor was considered part of the immune system without function in nerve cells. However, our study shows that it also plays an important role in the signal processing of the brain," explains Professor Dietmar Schmitz, Speaker for the DZNE-Site Berlin and Director of the Neuroscience Research Center of the Charité (NWFZ/NeuroCure). Schmitz coordinated the current study, which involved Berlin colleagues and also scientists from the University of Bonn and from the "National Institute on Drug Abuse" of the US.

As the researchers demonstrated in an animal model, the CB2 receptor raises the excitation threshold of in the hippocampus. "Operation of the brain critically depends on the fact that sometimes have an exciting impact on downstream cells and in other cases they have a suppressing effect," says Dr Vanessa Stempel, lead author of the current publication, who is now doing research in Cambridge, UK. "The CB2 receptor works like a set screw by which such communication processes can be adjusted."

Component of the "endocannabinoid system"

The CB2 receptor is part of the endocannabinoid system (ECS). This family of receptors and signaling substances exists in many organisms including humans. It is a biochemical control system which is involved in the regulation of numerous physiological processes. Its name refers to the fact that chemicals derived from the cannabis plant bind to receptors of the ECS. So far, there are two known types of these receptors: The CB2 receptor has no psychoactive effect. Hence, the mind-altering effects triggered by the consumption of cannabis are ascribed to the "cannabinoid type 1 receptor".

Potential therapeutic applications

The results of the current study could contribute to a better understanding of disease mechanisms and provide a starting point for novel medications. "Brain activity is disturbed in schizophrenia, depression, Alzheimer's disease and other neuropsychiatric disorders. Pharmaceuticals that bind to the CB2 receptor could possibly influence the activity of and thus become part of a therapy," Professor Schmitz concludes.


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More information: A. Vanessa Stempel et al, Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus, Neuron (2016). DOI: 10.1016/j.neuron.2016.03.034
Journal information: Neuron

Provided by German Center for Neurodegenerative Diseases
Citation: Neuroscientists discover previously unknown function of cannabinoid receptor (2016, May 2) retrieved 24 August 2019 from https://medicalxpress.com/news/2016-05-neuroscientists-previously-unknown-function-cannabinoid.html
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May 04, 2016
CBD in cannabis is a fantastic substance, and its a crime against humanity that its use has been suppressed in favor of the thug cop-judge-prison industrial complex. There is little need to develop synthetic CB receptor ligands considering that many of them have known to be extremely dangerous, and also given that CBD is already known to work well.

May 04, 2016
4-O-Methylhonokiol is another natural CB2 ligand which does pass the BBB. See https://en.wikipe...honokiol

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