Clonidine has antipyretic effect in ICU patients

Clonidine has antipyretic effect in ICU patients

(HealthDay)—For mechanically ventilated intensive care unit (ICU) patients, clonidine in addition to commonly used sedative agents has an antipyretic effect, according to a study published online June 6 in the Journal of Clinical Pharmacology.

Majid Mokhtari, M.D., from the Shahid Beheshti University of Medical Sciences in Iran, and colleagues conducted a single-center randomized trial to examine the effect of clonidine in addition to commonly used sedative agents in mechanically ventilated ICU patients. A group of 40 patients, aged 18 years or older, on mechanical ventilation for three days or longer were randomized to enteral clonidine or placebo in addition to the usual sedation/analgesia.

The researchers found that after adjustment for illness severity and time of follow-up, the odds ratio of having a temperature higher than 38.3 degrees Celsius was 3.96-fold higher in the (P = 0.049). After adjustment for the time of follow-up, a lower temperature (0.52 degrees Celsius) was seen in the clonidine group (P = 0.006).

"Our report is the first of its kind in humans which demonstrates possible antipyretic properties of enteral clonidine in the critically ill ," the authors write.

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Citation: Clonidine has antipyretic effect in ICU patients (2016, June 8) retrieved 2 February 2023 from https://medicalxpress.com/news/2016-06-clonidine-antipyretic-effect-icu-patients.html
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