Certain factors affect vitamin D levels in children with chronic kidney disease

June 16, 2016, American Society of Nephrology

Researchers have identified certain modifiable and non-modifiable factors associated with vitamin D deficiency in children with chronic kidney disease (CKD). The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), could help physicians protect the health of these young patients.

Vitamin D deficiency is common in children with chronic (CKD). In an attempt to understand why, a team led by Anke Doyon, MD and Franz Schaefer, MD (University of Heidelberg, Germany) looked at how various factors relate to D levels in 500 children with CKD who were residing in 12 European countries.

Among the major findings:

  • Two-thirds of the patients were classified as vitamin D deficient.
  • Patients who took vitamin D supplements had vitamin D levels that were 2 times higher than those who did not take supplements, and they had a lower prevalence of vitamin D deficiency.
  • Vitamin D levels were lower for certain kidney abnormalities, such as glomerulopathies
  • Vitamin D levels were lower in winter months than at other times of the year.
  • Certain genetic variants were also associated with vitamin D levels, but to a lesser extent than disease-associated factors and vitamin D supplementation.

"Vitamin D levels are influenced more strongly by seasonal factors, the type of disease and nutritional supplementation than by common variants in vitamin D regulating genes," said Dr. Doyon. "Supplementation practices should be reconsidered and intervention studies are needed to define guidelines how to monitor and treat vitamin D deficiency in children with ."

Explore further: Many with migraines have vitamin deficiencies, says study

More information: "Genetic, Environmental and Disease-Associated Correlates of Vitamin D Status in Children with CKD," CJASN, June 16, 2016, DOI: 10.2215/CJN.10210915

Related Stories

Many with migraines have vitamin deficiencies, says study

June 10, 2016
A high percentage of children, teens and young adults with migraines appear to have mild deficiencies in vitamin D, riboflavin and coenzyme Q10—a vitamin-like substance found in every cell of the body that is used to produce ...

Nutritional vitamin D supplements do not help treat anemia in dialysis patients

December 17, 2015
There is no role for nutritional vitamin D supplements in treating anemia in patients on hemodialysis, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Vitamin D supplements may benefit children with kidney disease

June 11, 2015
Maintaining normal vitamin D levels helps preserve kidney function in children with chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). ...

Holidays in the sun hold key to boosting vitamin D, study finds

May 17, 2016
Holidays abroad may hold the key to tackling Scotland's vitamin D deficiency, research suggests.

Low vitamin D linked to dry eye syndromes

February 10, 2016
(HealthDay)—Vitamin D deficiency is associated with dry eye and impaired tear function, according to a study published in the January issue of the International Journal of Rheumatic Diseases.

Low vitamin D linked with lower kidney function after transplantation

March 28, 2013
Vitamin D deficiency may decrease kidney function in transplant recipients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The finding suggests that vitamin ...

Recommended for you

New hope for cystic fibrosis

October 19, 2018
A new triple-combination drug treatment being trialled at the Mater Hospital in Brisbane could increase the life expectancy of patients with cystic fibrosis.

Bug guts shed light on Central America Chagas disease

October 18, 2018
In Central America, Chagas disease, or American trypanosomiasis, is spread by the "kissing bug" Triatoma dimidiata. By collecting DNA from the guts of these bugs, researchers reporting in PLOS Neglected Tropical Diseases ...

Rapid genomic sequencing of Lassa virus in Nigeria enabled real-time response to 2018 outbreak

October 18, 2018
Mounting a collaborative, real-time response to a Lassa fever outbreak in early 2018, doctors and scientists in Nigeria teamed up with researchers at Broad Institute of MIT and Harvard and colleagues to rapidly sequence the ...

Infectious disease consultation significantly reduces mortality of patients with bloodstream yeast infections

October 17, 2018
In a retrospective cohort study conducted at the University of Alabama at Birmingham Division of Infectious Diseases, patients with candidemia—a yeast infection in the bloodstream—had more positive outcomes as they relate ...

How drug resistant TB evolved and spread globally

October 17, 2018
The most common form of Mycobacterium tuberculosis (TB) originated in Europe and spread to Asia, Africa and the Americas with European explorers and colonialists, reveals a new study led by UCL and the Norwegian Institute ...

Marker may help target treatments for Crohn's patients

October 16, 2018
Crohn's disease (CD), a chronic inflammatory condition of the intestinal tract, has emerged as a global disease, with rates steadily increasing over the last 50 years. Experts have long suspected that CD likely represents ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.