Sub-set of stem cells found to minimize risks when used to treat damaged hearts

July 25, 2016, Public Library of Science
Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy. The study, published in PLOS Computational Biology, represents a development in novel strategies to repair and regenerate heart muscle and could improve stem cell treatments for heart attack patients. Credit: Jerry Reyes / Flickr

Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy. The study, published in PLOS Computational Biology, represents a development in novel strategies to repair and regenerate heart muscle and could improve stem cell treatments for heart attack patients.

Myocardial infarction—better known as a heart attack—strikes on average every 43 seconds in America. This has motivated novel cardiotherapeutic strategies to repair and regenerate , including human mesenchymal stem cell (hMSC) therapy. However, in clinical trials the benefits have often been modest and transient, which reflects our limited mechanistic knowledge of how hMSCs impact cardiac function.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

Their computer simulations demonstrate that one family of human minimizes disturbances in cardiac single-cell and tissue level electrical activity. By identifying the benefits of using this specific sub-set of human mesenchymal stem cells this research may enhance safety for receiving . This advance could therefore lead to new clinical trials and future improvements in treatment of patients with heart failure.

This study provides a new mathematical model that could be incorporated into future computational studies on mesenchymal stem cells. It also provides novel insight into human mesenchymal stem cell-heart cell interactions that can guide future experimental studies to understand the mechanisms underlying mesenchymal stem cell therapy for the heart.

Explore further: Muscles on-a-chip provide insight into cardiac stem cell therapies

More information: Mayourian J, Savizky RM, Sobie EA, Costa KD (2016) Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes. PLoS Comput Biol 12(7): e1005014. DOI: 10.1371/journal.pcbi.1005014

Related Stories

Muscles on-a-chip provide insight into cardiac stem cell therapies

February 8, 2016
Stem cell-derived heart muscle cells may fail to effectively replace damaged cardiac tissue because they don't contract strongly enough, according to a study in The Journal of Cell Biology. The study, "Coupling Primary and ...

A tool for isolating progenitor cells from human heart tissue could lead to heart repair

October 7, 2015
A*STAR researchers and colleagues have developed a method to isolate and expand human heart stem cells, also known as cardiac progenitor cells, which could have great potential for repairing injured heart tissue.

Novel stem cell approach promising for heart failure

August 3, 2015
(HealthDay)—A new method for delivering stem cells to damaged heart muscle has shown early promise in treating severe heart failure, researchers report online July 27 in Stem Cells Translational Medicine.

New research reveals combined cell therapy enhances cardiac performance following heart attack

November 11, 2015
A new study from the Interdisciplinary Stem Cell Institute (ISCI) at the University of Miami Miller School of Medicine finds that combination stem cell therapy, using c-kit+ cardiac stem cells (CSCs) and mesenchymal stem ...

Heart failure patients have improved outcomes following investigational stem cell treatment

April 4, 2016
An investigational stem cell therapy derived from patients' own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute.

Therapy using stem cells, bone marrow cells, appears safe for patients with ischemic cardiomyopathy

November 18, 2013
Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection (TESI) with autologous mesenchymal stem cells and ...

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.