TBC1D4 mutation common in north american inuit

<i>TBC1D4</i> mutation common in north american inuit
(HealthDay)—More than one-quarter of Canadian and Alaskan Inuit have the TBC1D4 mutation resulting in elevated postprandial glucose, and those with prediabetes and type 2 diabetes have increased risk of remaining undiagnosed, according to a study published online Aug. 25 in Diabetes Care.

Despoina Manousaki, M.D., from McGill University in Montreal, and colleagues examined the frequency and effect of the TBC1D4 mutation on and type 2 diabetes diagnosis among Canadian and Alaskan Inuit. Exome sequencing was performed in 114 Inuit from Nunavik, Canada, and Sanger sequencing was performed in 1,027 Alaskan Inuit.

The researchers found that 27 percent of Canadian and Alaskan Inuit had the TBC1D4 mutation, which was strongly associated with higher glucose and insulin two hours after an oral glucose load in homozygote carriers. The odds of remaining undiagnosed were increased for TBC1D4 carriers with prediabetes and type 2 diabetes, compared with noncarriers, unless prostprandial glucose values were tested (odds ratio, 5.4). Thirty-two percent of carriers with prediabetes or type 2 diabetes would remain undiagnosed without an test (OGTT).

"Disruption of TBC1D4 is common among North American Inuit, resulting in exclusively elevated postprandial glucose. This leads to underdiagnosis of type 2 diabetes, unless an OGTT is performed," the authors write. "Accounting for genetic factors in the care of Inuit with diabetes provides an opportunity to implement precision medicine in this population."


Explore further

Serum prolactin in pregnancy predicts prediabetes / diabetes

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2016 HealthDay. All rights reserved.

Citation: TBC1D4 mutation common in north american inuit (2016, August 31) retrieved 27 June 2019 from https://medicalxpress.com/news/2016-08-tbc1d4-mutation-common-north-american.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more