Anticoagulation cuts TEC rate in adults after fontan surgery

Anticoagulation cuts TEC rate in adults after fontan surgery

(HealthDay)—For adults with atrial arrhythmia after Fontan operation, the risk of thrombotic and embolic complications (TEC) is reduced with anticoagulation therapy, according to research published in the Sept. 20 issue of the Journal of the American College of Cardiology.

Alexander C. Egbe, M.D., M.P.H., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a of 278 adults with atrial arrhythmia after Fontan operation. Patients were followed for 88 ± 14 months. Patients were divided into (91 patients), antiplatelet (181 patients), and no therapy (six patients) cohorts.

The researchers found that there were 97 TEC in 81 patients (29 percent), of which 32 and 65 were systemic and nonsystemic, respectively, yielding an event rate of 2.1 and 4.4 systemic and nonsystemic TEC per 100 patient-years, respectively. At five and 10 years, the prevalence of TEC was 18 and 55 percent, respectively. Atriopulmonary connection was identified as a risk factor for TEC (hazard ratio, 2.31), and TEC correlated with elevated risk of death and hospitalization (P < 0.0001). Anticoagulation was protective against TEC and correlated with a reduction in the risk of TEC by 2.5 TEC per 100 patient-years. Anticoagulation also correlated with reduced risk of death and hospitalization (P = 0.02). In 7 percent of bleeding complications occurred, with similar rates in all groups.

"Anticoagulation was associated with lower TEC rate and lower risk of death and hospitalization, without a significant increase in bleeding risk," the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.


Explore further

Study suggests ways to improved immunity in older people

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Anticoagulation cuts TEC rate in adults after fontan surgery (2016, September 16) retrieved 17 November 2019 from https://medicalxpress.com/news/2016-09-anticoagulation-tec-adults-fontan-surgery.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments