Additional benefit of omega-3 fatty acids for the clearance of metabolites from the brain

October 26, 2016

New research published online in The FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-β peptides, a primary culprit in Alzheimer's disease.

To make this discovery, scientists first used transgenic fat-1 mice, which express high endogenous omega-3 polyunsaturated (PUFAs) in the brain, to investigate the effect of omega-3 PUFAs on the clearance function of the glymphatic system. Compared to the wild-type mice, the fat-1 mice with enriched endogenous omega-3 PUFAs significantly promote the clearance function of the lymphatic system, including the Aβ clearance from the brain. Wild-type mice were supplemented with , which contains high concentrations of omega-3 PUFAs, and found that fish oil-supplemented mice also improved the clearance function of the glymphatic system compared to the control mice without . Omega-3 PUFAs help maintain the brain homeostasis, which may provide benefits in a number of neurological diseases, such as Alzheimer's disease, traumatic brain injury, and sleep impairment, among others.

"These now-famous fatty acids have been the subject of major studies both in academia and industry. Just when we thought we had heard everything, here is something new, and it is provocative indeed," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "This study should not turn attention away from the roles of these substances in maintaining vascular health, but neither should they restrict our view. The brain is an extremely vascularized organ, while we might also bear in mind that may impact neurons, glia, and astrocytes themselves."

Explore further: Different types of PUFAs are associated with differential risks for type 2 diabetes

More information: H. Ren et al, Omega-3 polyunsaturated fatty acids promote amyloid-  clearance from the brain through mediating the function of the glymphatic system, The FASEB Journal (2016). DOI: 10.1096/fj.201600896

Related Stories

Different types of PUFAs are associated with differential risks for type 2 diabetes

July 19, 2016
Different types of circulating polyunsaturated fatty acids (PUFAs) are associated with differing future risk of type 2 diabetes, according to a large European study authored by Nita Forouhi of the MRC Epidemiology Unit at ...

Stroke-like brain damage is reduced in mice injected with omega-3s

August 22, 2016
Researchers from Columbia University Medical Center (CUMC) found that omega-3 fatty acids reduced brain damage in a neonatal mouse model of stroke.

Why fish intake by pregnant women improves the growth of a child's brain

January 14, 2016
Researchers at Tohoku University's School of Medicine have found an explanation for the correlation between eating fish during pregnancy, and the health of the baby's brain.

Novel lipid mediators may play role in omega-3 PUFA effects

June 25, 2016
(HealthDay)—Novel lipid mediators may be involved in the beneficial effects associated with omega-3 polyunsaturated fatty acids (PUFAs) in obesity, according to a study published online June 16 in Diabetes.

Omega-3 PUFAs can reduce smoking, cut tobacco craving

November 13, 2014
(HealthDay)—Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) can reduce daily smoking and tobacco craving, according to a study published in the Journal of Psychopharmacology.

High serum omega-6 polyunsaturated fatty acid concentrations linked to lower risk of type 2 diabetes

March 24, 2016
A new study from the University of Eastern Finland shows that high serum omega-6 polyunsaturated fatty acid concentrations are linked to a significantly reduced risk of type 2 diabetes. The findings were published in the ...

Recommended for you

Study finds being in a good mood for your flu jab boosts its effectiveness

September 25, 2017
New research by a team of health experts at the University of Nottingham has found evidence that being in a positive mood on the day of your flu jab can increase its protective effect.

New tool demonstrates high cost of lack of sleep in the workplace

September 25, 2017
Sleep disorders and sleep deficiency are hidden costs that affect employers across America. Seventy percent of Americans admit that they routinely get insufficient sleep, and 30 percent of U.S. workers and 44 percent of night ...

Maternal diet could affect kids' brain reward circuitry

September 25, 2017
Researchers in France found that rats who ate a junk food diet during pregnancy had heavier pups that strongly preferred the taste of fat straight after weaning. While a balanced diet in childhood seemed to reduce the pups' ...

Breathing dirty air may harm kidneys, study finds

September 21, 2017
Outdoor air pollution has long been linked to major health conditions such as heart disease, stroke, cancer, asthma and chronic obstructive pulmonary disease. A new study now adds kidney disease to the list, according to ...

Excess dietary manganese promotes staph heart infection

September 21, 2017
Too much dietary manganese—an essential trace mineral found in leafy green vegetables, fruits and nuts—promotes infection of the heart by the bacterium Staphylococcus aureus ("staph").

Being active saves lives whether a gym workout, walking to work or washing the floor

September 21, 2017
Physical activity of any kind can prevent heart disease and death, says a large international study involving more than 130,000 people from 17 countries published this week in The Lancet.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.