Transplantation with induced neural stem cells improves stroke recovery in mice

October 11, 2016, Cell Transplantation Center of Excellence for Aging and Brain Repair

In a study to determine whether induced neural stem cells (iNSCs), a type of somatic cell directly differentiated into neural stem cells, could exert therapeutic effects when transplanted into mice modeled with ischemic stroke, researchers found that the cells promoted survival and functional recovery. Additionally, they discovered that when administered during the acute phase of stroke, iNSCs protected the brain from ischemia-related damage.

In contrast to other studies that have induced to become (iPSCs), which can then be differentiated into , this study directly converted somatic cells into . Researchers concluded that in addition to iNSC transplantation improving survival rate, results also demonstrated reduced infarct volume in the brain and enhanced sensorimotor function in the mice modeled with stroke.

The study will be published in a future issue of Cell Transplantation.

"We observed multiple therapeutic effects when using these cells to treat stroke in mice," said Dr. Koji Abe, Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science. "The iNSCs did not produce any adverse responses in the animals, including tumor formation, which may suggest they are safer than regular iPSCs. Further studies are needed to confirm this cell type as a candidate for cell replacement therapy for stroke."

"Use of iNSCs may improve the efficacy of cell transplantation procedures for stroke since they are able to be derived directly from other cells without the need for extra steps," said Dr. Shinn-Zong (John) Lin, Tzu Chi Hospital, Hualien City, Taiwan. "This is highly desirable in stroke, which has a narrow window in which the brain is most responsive to treatment. Whether the therapeutic effects produced by iNSCs are attributable to cell replacement or to secreted factors (paracrine effects), this method may be promising for treating early."

Explore further: Stem cell-based transplantation approach improves recovery from stroke

More information: , Novel therapeutic transplantation of induced neural stem cells for stroke, Cell Transplantation (2016). DOI: 10.3727/096368916X692988

Related Stories

Stem cell-based transplantation approach improves recovery from stroke

June 19, 2014
Stroke is a leading cause of death and disability in developed countries, and there is an urgent need for more clinically effective treatments. A study published by Cell Press June 19th in Stem Cell Reports reveals that simultaneous ...

Gamma-ray irradiation improves safety of cell therapy for Parkinson's disease

June 23, 2016
New Rochelle, NY, June 23, 2016 -Replacing dopamine-producing cells in the brain represents a promising therapeutic approach in Parkinson's disease, and a new study shows how post-transplantation gamma-ray irradiation can ...

Stem cell therapy heals injured mouse brain

August 22, 2016
Permanent brain damage from a stroke may be reversible thanks to a developing therapeutic technique, a USC-led study has found.

Future heat stroke treatment found in dental pulp stem cells

June 5, 2014
Scientists in Taiwan have found that intravenous injections of stem cells derived from human exfoliated deciduous tooth pulp (SHED) have a protective effect against brain damage from heat stroke in mice. Their finding was ...

Neural stem cell transplants promote Parkinson's recovery in non-human primates

June 7, 2016
A multi-center team of researchers in the U.S. testing the potential of cell therapy for treating Parkinson's disease (PD) has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human ...

Recommended for you

New inflammation inhibitor discovered

November 16, 2018
A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, the researchers were able ...

Gut hormone and brown fat interact to tell the brain it's time to stop eating

November 15, 2018
Researchers from Germany and Finland have shown that so-called "brown fat" interacts with the gut hormone secretin in mice to relay nutritional signals about fullness to the brain during a meal. The study, appearing November ...

Brain, muscle cells found lurking in kidney organoids grown in lab

November 15, 2018
Scientists hoping to develop better treatments for kidney disease have turned their attention to growing clusters of kidney cells in the lab. One day, so-called organoids—grown from human stem cells—may help repair damaged ...

How the Tasmanian devil inspired researchers to create 'safe cell' therapies

November 15, 2018
A contagious facial cancer that has ravaged Tasmanian devils in southern Australia isn't the first place one would look to find the key to advancing cell therapies in humans.

Researchers discover important connection between cells in the liver

November 15, 2018
University of Minnesota Medical School researchers have made a discovery which could lead to a new way of thinking about how disease pathogenesis in the liver is regulated, which is important for understanding the condition ...

Precision neuroengineering enables reproduction of complex brain-like functions in vitro

November 14, 2018
One of the most important and surprising traits of the brain is its ability to dynamically reconfigure the connections to process and respond properly to stimuli. Researchers from Tohoku University (Sendai, Japan) and the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.