Cause of inflammation in diabetes identified

November 2, 2016
Too much fat in the diet promotes insulin resistance by spurring chronic inflammation. In the image above, immune cells (shown in green) produce fatty acids that contribute to diabetes-related inflammation. Researchers at Washington University School of Medicine have developed a way to block production of fatty acids in these immune cells in mice and protect them from diet-induced diabetes. Credit: Semenkovich lab/Washington University School of Medicine

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School of Medicine in St. Louis have identified a possible trigger of chronic inflammation.

Too much fat in the diet promotes insulin resistance by spurring chronic inflammation. But the researchers discovered, in mice, that when certain immune cells can't manufacture fat, the mice don't develop diabetes and inflammation, even when consuming a high-fat diet.

The study is available Nov. 2 as an advance online publication from the journal Nature.

"The number of people with diabetes has quadrupled worldwide over the last 20 years," said senior investigator Clay F. Semenkovich, the Irene E. and Michael M. Karl Professor and director of the Division of Endocrinology, Metabolism & Lipid Research at the School of Medicine. "We have made modest progress in making it less likely for some people with diabetes to have heart attacks and strokes. However, those receiving optimal therapy are still much more likely to die from complications driven by chronic inflammation that is, at least in part, generated by these immune cells.

"But by blocking the production of fat inside these cells, it may be possible to prevent inflammation in people with diabetes and even in other conditions, such as arthritis and cancer, in which chronic inflammation plays a role. This could have a profound impact on health."

Semenkovich's team made genetically altered mice that could not make the enzyme for fatty acid synthase (FAS) in immune cells called macrophages. Without the enzyme, it was impossible for the mice to synthesize fatty acids, a normal part of cell metabolism.

"We were surprised to find that the mice were protected from diet-induced diabetes," said first author Xiaochao Wei, PhD, an instructor of medicine. "They did not develop the and diabetes that normally would have been induced by a ."

Through a series of experiments in the animals and in cell cultures, the researchers, including Douglas F. Covey, PhD, a professor of developmental biology and biochemistry, and Daniel S. Ory, MD, a professor of medicine and of cell biology and physiology, found that if macrophages could not synthesize fat from within, the external membranes of those cells could not respond to fat from outside the cells. That prevented the cells from contributing to inflammation.

But eliminating inflammation altogether is not the answer to preventing diabetic complications because inflammation is also vital for clearing infectious pathogens from the body and helps wounds heal. Still, Semenkovich said the new findings may have profound clinical implications.

"An inhibitor of fatty acid synthase actually is now in clinical trials as a potential cancer treatment," he explained. "And other drugs have been developed to inhibit fatty acid synthase in diabetes, too. One possibility that our work suggests is that altering the lipid content in the cell membrane may help block cancer metastases and complications of diabetes."

Drugs currently in use to block fatty acid synthase, as well as other developing strategies, potentially could allow for to be blocked, without completely eliminating the ability of macrophages to fight infection.

Explore further: Diabetes may start in the intestines, research suggests

More information: Xiaochao Wei et al, Fatty acid synthesis configures the plasma membrane for inflammation in diabetes, Nature (2016). DOI: 10.1038/nature20117

Related Stories

Diabetes may start in the intestines, research suggests

February 15, 2012

Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark of diabetes ...

Recommended for you

Omega-3 supplements can prevent childhood asthma

December 29, 2016

Taking certain omega-3 fatty acid supplements during pregnancy can reduce the risk of childhood asthma by almost one third, according to a new study from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) ...

Cause of inflammation in diabetes identified

November 2, 2016

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School ...

2 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

dwyerste1966
Nov 03, 2016
This comment has been removed by a moderator.
jhnycmltly
not rated yet Nov 04, 2016
"chlorogenic acid significantly inhibited fatty acid synthase,"

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.