Competing risks influence warfarin, thromboembolism link

Competing risks influence warfarin, thromboembolism link

(HealthDay)—For patients with nonvalvular atrial fibrillation, warfarin is associated with a reduction in thromboembolism, although the correlation is attenuated after accounting for competing death events, according to a study published online Nov. 12 in the Journal of the American Geriatrics Society.

Jeffrey M. Ashburner, Ph.D., M.P.H., from Massachusetts General Hospital in Boston, and colleagues conducted a involving 13,559 adults with nonvalvular between 1996 and 2003. The authors estimated cause-specific hazard ratios for and the competing risk event (all-cause death) with longitudinal warfarin exposure.

The researchers found that the rate of death was much higher in the group not taking warfarin versus those taking warfarin (8.1 versus 5.5 deaths/100 person-years). The cause-specific hazard ratio indicated a large decrease in thromboembolism with warfarin use (adjusted hazard ratio, 0.57); after for competing death events, the correlation was attenuated substantially (adjusted hazard ratio, 0.87). The results for models that did and did not account for competing risks were similar in analyses limited to one year of follow-up.

"Analyses accounting for competing death events may provide a more-realistic estimate of the longer-term stroke prevention benefits of anticoagulants than traditional noncompeting risk analyses for individuals with atrial fibrillation, particularly those who are not currently treated with anticoagulants," the authors write.

Several authors disclosed financial ties to the biopharmaceutical and medical technology industries.

Explore further

Atrial fibrillation patients are at increased risk of dementia, regardless of anticoagulation use

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Competing risks influence warfarin, thromboembolism link (2016, November 17) retrieved 23 October 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more