Is dementia in older women tied to 20-year rate of weight loss?

December 27, 2016

(HealthDay)—For women surviving into late life, the rate of weight loss over 20 years is associated with development of mild cognitive impairment (MCI) or dementia, according to a study published online Dec. 19 in the Journal of the American Geriatrics Society.

Erin S. LeBlanc, M.D., M.P.H., from Kaiser Permanente Northwest in Portland, Ore., and colleagues conducted a cohort study involving 1,289 older community-dwelling women (mean baseline age: 68 and 88 at cognitive testing). Participants underwent body weight measures repeatedly over 20 years.

The researchers found that the chance of developing MCI or dementia was increased for women with greater rate of weight loss over 20 years. Each 0.5 kg/year decrease resulted in 30 percent increased odds of MCI/dementia in age/education/clinic-adjusted base models (odds ratio [OR], 1.30; 95 percent confidence interval [CI], 1.14 to 1.49). After further adjustment for age, education, clinic, depression, and walking speed, each 0.5 kg/year decrease was associated with a 17 percent increased odds of MCI/dementia (OR, 1.17; 95 percent CI, 1.02 to 1.35). Variability in weight was significant in base models. The odds of MCI/dementia were increased 11 percent for each 1 percent average deviation from each woman's predicted weight curve (OR, 1.11; 95 percent CI, 1.04 to 1.18). After full adjustment the estimate was attenuated (OR, 1.06; 95 percent CI, 0.99 to 1.14).

"Rate of over 20 years was associated with development of MCI or in surviving past 80 years," the authors write.

One author's institution received funding from pharmaceutical companies for unrelated projects.

Explore further: Potentially unsafe med scripts up for dual users with dementia

More information: Full Text (subscription or payment may be required)

Related Stories

Potentially unsafe med scripts up for dual users with dementia

December 6, 2016
(HealthDay)—For veterans with dementia, Veterans Affairs (VA)-Medicare Part D (dual-system) users have increased rates of potentially unsafe medication (PUM) prescribing, according to a study published online Dec. 6 in ...

Greater weight loss during aging associated with increased risk for MCI

February 1, 2016
Increasing weight loss per decade as people age from midlife to late life was associated with an increased risk of mild cognitive impairment (MCI), according to an article published online by JAMA Neurology.

ADT use not linked to dementia in prostate cancer

November 28, 2016
(HealthDay)—For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

Late-life depression associated with prevalent mild cognitive impairment, increased risk of dementia

December 31, 2012
Depression in a group of Medicare recipients ages 65 years and older appears to be associated with prevalent mild cognitive impairment and an increased risk of dementia, according to a report published Online First by Archives ...

In nursing homes, statins often continued in advanced dementia

December 15, 2014
(HealthDay)—For nursing home (NH) residents with dementia taking statins, most continue statins with the progression to advanced dementia, according to research published in the November issue of the Journal of the American ...

Among the oldest adults, poor balance may signal higher risk for dementia

July 25, 2016
The number of people living well into their 90s is projected to quadruple by 2050. By mid-century, nearly 9 million people will be 90-years-old or older. In a first-of-its-kind study published in the Journal of the American ...

Recommended for you

Lifestyle changes to stave off Alzheimer's? Hints, no proof

July 20, 2017
There are no proven ways to stave off Alzheimer's, but a new report raises the prospect that avoiding nine key risks starting in childhood just might delay or even prevent about a third of dementia cases around the world.

Blood test identifies key Alzheimer's marker

July 19, 2017
A new study led by researchers at Washington University School of Medicine in St. Louis suggests that measures of amyloid beta in the blood have the potential to help identify people with altered levels of amyloid in their ...

Steering an enzyme's 'scissors' shows potential for stopping Alzheimer's disease

July 19, 2017
The old real estate adage about "location, location, location" might also apply to the biochemical genesis of Alzheimer's disease, according to new research from the University of British Columbia.

Brain scans may change care for some people with memory loss

July 19, 2017
Does it really take an expensive brain scan to diagnose Alzheimer's? Not everybody needs one but new research suggests that for a surprising number of patients whose memory problems are hard to pin down, PET scans may lead ...

Can poor sleep boost odds for Alzheimer's?

July 18, 2017
(HealthDay)— Breathing problems during sleep may signal an increased risk for Alzheimer's disease, a trio of studies suggests.

Hearing is believing: Speech may be a clue to mental decline

July 17, 2017
Your speech may, um, help reveal if you're uh ... developing thinking problems. More pauses, filler words and other verbal changes might be an early sign of mental decline, which can lead to Alzheimer's disease, a study suggests.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.