Is dementia in older women tied to 20-year rate of weight loss?
Erin S. LeBlanc, M.D., M.P.H., from Kaiser Permanente Northwest in Portland, Ore., and colleagues conducted a cohort study involving 1,289 older community-dwelling women (mean baseline age: 68 and 88 at cognitive testing). Participants underwent body weight measures repeatedly over 20 years.
The researchers found that the chance of developing MCI or dementia was increased for women with greater rate of weight loss over 20 years. Each 0.5 kg/year decrease resulted in 30 percent increased odds of MCI/dementia in age/education/clinic-adjusted base models (odds ratio [OR], 1.30; 95 percent confidence interval [CI], 1.14 to 1.49). After further adjustment for age, education, clinic, depression, and walking speed, each 0.5 kg/year decrease was associated with a 17 percent increased odds of MCI/dementia (OR, 1.17; 95 percent CI, 1.02 to 1.35). Variability in weight was significant in base models. The odds of MCI/dementia were increased 11 percent for each 1 percent average deviation from each woman's predicted weight curve (OR, 1.11; 95 percent CI, 1.04 to 1.18). After full adjustment the estimate was attenuated (OR, 1.06; 95 percent CI, 0.99 to 1.14).
One author's institution received funding from pharmaceutical companies for unrelated projects.
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