Lowest glucose variability for insulin + GLP-1 RA in T2DM

Lowest glucose variability for insulin + GLP-1 RA in T2DM

(HealthDay)—For patients with type 2 diabetes, the lowest glucose variability (GV) and hypoglycemia is seen for patients using basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), according to a study published online Dec. 2 in Diabetes Care.

Harpreet S. Bajaj, M.D., M.P.H., from LMC Diabetes & Endocrinology in Brampton, Canada, and colleagues compared GV using continuous monitoring (CGM) in with well-controlled type 2 diabetes using four regimens: + oral drugs (BO), BGLP, premixed insulin (PM), and basal-bolus insulin (BB). One hundred sixty patients underwent six-day masked CGM in four equal insulin regimen cohorts.

The researchers found that the primary outcome of the daily glucose standard deviation was significantly lower in the BGLP cohort compared with the BO (P = 0.03), PM (P = 0.01), and BB (P < 0.01) cohorts; these correlations persisted after adjustment for age, body mass index, type 2 diabetes duration, and hemoglobin A1c. The BGLP cohort had the lowest daily hypoglycemia outcomes on CGM.

"These observed benefits in GV and hypoglycemia may contribute to the cardiovascular outcome reduction seen with GLP-1 RA therapy and should be investigated further," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.


Explore further

Premixed insulin ups hypoglycemia in inpatients

More information: Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2016 HealthDay. All rights reserved.

Citation: Lowest glucose variability for insulin + GLP-1 RA in T2DM (2016, December 20) retrieved 17 October 2019 from https://medicalxpress.com/news/2016-12-lowest-glucose-variability-insulin-glp-.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more