Quenched activity-based probe imaging beneficial in NMSC

January 30, 2017

(HealthDay)—Quenched activity-based probe imaging can discriminate cancer from normal appearing skin tissue, according to a study published in the February issue of the Journal of the American Academy of Dermatology.

Ethan Walker, M.D., Ph.D., from Case Western Reserve University in Cleveland, and colleagues examined the use of quenched activity-based probe imaging to discriminate cancerous versus normal-appearing . They applied the quenched activity-based probe GB119 to non-melanoma skin cancers (NMSCs) excised from 68 patients. Activation of the probe was validated for hematoxylin-eosin-confirmed cancerous tissue versus normal-appearing skin tissue.

The researchers found that the overall estimated sensitivity and specificity were 0.989 (95 percent confidence interval, 0.940 to 1.00) and 0.894 (95 percent confidence interval, 0.769 to 0.965), respectively, for differentiation of and from normal-appearing skin with topical application of the probe. Compared with conventional hematoxylin-eosin-based pathology, probe activation accurately defined peripheral margins of NMSC.

"These findings merit further studies to determine whether quenched activity-based technology may enable cost-effective increased cure rates for patients with NMSC by reducing re-excision and recurrence rates with a rapid and easily interpretable technological advance," the authors write.

Several authors disclosed financial ties to Akrotome Imaging.

Explore further: Skin cancer incidence up after pancreas transplantation

More information: Full Text (subscription or payment may be required)

Related Stories

Skin cancer incidence up after pancreas transplantation

September 21, 2012
(HealthDay)—Nonmelanoma skin cancers (NMSCs) commonly occur after pancreas transplantation (PT), particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal ...

Some sun protection behaviors up with history of NMSC

May 23, 2016
(HealthDay)—Individuals with previous nonmelanoma skin cancer (NMSC) are more likely to engage in certain sun protection behaviors than those without previous NMSC, according to a study published online May 16 in the Journal ...

Potential new tool to aid breast cancer surgery (Update)

November 30, 2016
University of Adelaide researchers have developed an optical fiber probe that distinguishes breast cancer tissue from normal tissue - potentially allowing surgeons to be much more precise when removing breast cancer.

Some RA treatments up second nonmelanoma skin cancer risk

October 29, 2015
(HealthDay)—For patients with rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) with prior nonmelanoma skin cancer (NMSC), the risk of second NMSC varies with different treatments, according to a study published ...

Australia leads world in skin cancer incidence but lacks reporting

March 5, 2015
Research published this week in the Australasian Journal of Dermatology confirms that Australia has the highest incidence of skin cancers in the world but lacks in national reporting of the statistics.

Recommended for you

Anti-cancer chemotherapeutic agent inhibits glioblastoma growth and radiation resistance

July 24, 2017
Glioblastoma is a primary brain tumor with dismal survival rates, even after treatment with surgery, chemotherapy and radiation. A small subpopulation of tumor cells—glioma stem cells—is responsible for glioblastoma's ...

New therapeutic approach for difficult-to-treat subtype of ovarian cancer identified

July 24, 2017
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

Immune cells the missing ingredient in new bladder cancer treatment

July 24, 2017
New research offers a possible explanation for why a new type of cancer treatment hasn't been working as expected against bladder cancer.

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.