Progress toward HIV cure highlighted

February 10, 2017
Credit: Mary Ann Liebert, Inc., publishers

A comprehensive collection of articles describing the broad scope and current status of this global effort is published in a special issue of AIDS Research and Human Retroviruses.

Leonardo Calza and coauthors from University of Bologna (Italy), have shown that statins, which are commonly prescribed to lower , can also significantly reduce the concentration of D-dimer, a marker of coagulation, and of two markers of inflammation known as interleukins (IL-8 and IL-10) in HIV-infected individuals. The anti-inflammatory properties of statins and their potential effects on blood clot formation could help reduce HIV-associated comorbidities such as cardiovascular disease. The researchers present their findings in the article entitled "Significant Decrease in Plasma Levels of D-Dimer, Interleukin-8, and Interleukin-12 After a 12-Month Treatment with Rosuvastatin in HIV-Infected Patients Under Antiretroviral Therapy."

In the article "Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV," Lindsay Wallace and coauthors from Dalhousie University (Halifax, Canada), University of Modena and Reggio Emilia (Modena, Italy), and University of California San Diego, identified factors associated with better cognitive function among HIV-infected individuals 50 years of age or older being treated with . The researchers found that study participants who scored lower on a frailty index were less likely to have neurocognitive impairment.

Heather Grome and colleagues from Vanderbilt University Medical Center (Nashville, TN), report on the role that persistent T-cell and in HIV-infected adults on combination antiretroviral therapy may have on the function of arterial blood vessels. The effects of HIV-related chronic on the arterial lining and vascular smooth muscle may promote the development of atherosclerosis and plaque formation that can lead to cardiovascular disease. The researchers present measures of blood-based inflammatory and immune activation markers and the results of brachial artery flow-mediated dilation on ultrasound in the article entitled "Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV."

"It is becoming clear that although HIV-infected individuals can control the amount of virus in their system with antiviral treatments, there are still negative health consequences that look like premature aging, including and cognitive impairment," says Thomas Hope, PhD, Editor-in-Chief of AIDS Research and Human Retroviruses and Professor of Cell and Molecular Biology at Northwestern University, Feinberg School of Medicine (Chicago, IL). "These three papers and others in the Cure issue seek a better understanding of the cause of this accelerated aging. The Calza article suggests that taking statins, which reduce lipid levels, may be an effective treatment to reduce damaging inflammation in HIV-infected individuals taking appropriate antiviral therapy,"

Explore further: Antiretroviral therapy may not be enough to reduce HIV-associated arterial inflammation

More information: Leonardo Calza et al, Significant Decrease in Plasma Levels of D-Dimer, Interleukin-8, and Interleukin-12 After a 12-Month Treatment with Rosuvastatin in HIV-Infected Patients Under Antiretroviral Therapy, AIDS Research and Human Retroviruses (2017). DOI: 10.1089/aid.2016.0134

Related Stories

Antiretroviral therapy may not be enough to reduce HIV-associated arterial inflammation

May 25, 2016
Initiating antiretroviral therapy (ART) soon after diagnosis of an HIV infection did not prevent the progression of significant arterial inflammation in a small group of previously untreated patients. The findings from a ...

Anti-inflammatory drug may prevent rapid aging in people with HIV

February 22, 2016
New research from the University of Alberta's School of Dentistry shows that a commonly used cholesterol-lowering drug could help people with HIV live longer and enjoy an improved quality of life.

Obesity and weight gain in HIV-infected adults on antiretroviral therapy: What's the harm?

February 3, 2016
The percentage of HIV-infected adults who were obese-body mass index >30 kg/m2-when they began antiretroviral therapy (ART) doubled over a 12-year period. After 3 years of ART, 18% of adults who were overweight at initiation ...

Early antiretroviral therapy reduces gut inflammation in HIV+ individuals

July 7, 2016
Combination antiretroviral therapy (cART) suppresses HIV replication and significantly slows the progression of disease, enabling HIV+ individuals to effectively manage infection for long periods. One of the manifestations ...

HIV-infected young males have higher rates of bone loss than females

March 10, 2016
Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than in females. Researchers led by Grace Aldrovandi, MD, chief of the Division of Infectious Diseases at Children's Hospital Los ...

Increased cardiovascular risk in HIV-infected patients may relate to arterial inflammation

July 22, 2012
The elevated risk of cardiovascular disease seen in patients infected with HIV appears to be associated with increased inflammation within the arteries, according to a study that will appear in a special issue of JAMA published ...

Recommended for you

Study suggests a way to stop HIV in its tracks

December 1, 2017
When HIV-1 infects an immune cell, the virus travels to the nucleus so quickly there's not enough time to set off the cell's alarm system.

Discovery puts the brakes on HIV's ability to infect

November 30, 2017
Viewed with a microscope, the virus faintly resembles a pineapple—the universal symbol of welcome. But HIV, the virus that causes AIDS, is anything but that. It has claimed the lives of more than 35 million people so far.

Rising levels of HIV drug resistance

November 30, 2017
HIV drug resistance is approaching and exceeding 10% in people living with HIV who are about to initiate or reinitiate first-line antiretroviral therapy, according to the largest meta-analysis to date on HIV drug resistance, ...

Male circumcision and antiviral drugs appear to sharply reduce HIV infection rate

November 29, 2017
A steep drop in the local incidence of new HIV infections accompanied the rollout of a U.S.-funded anti-HIV program in a large East-African population, according to a study led by researchers at Johns Hopkins Bloomberg School ...

Combination HIV prevention reduces new infections by 42 percent in Ugandan district

November 29, 2017
A study published today in the New England Journal of Medicine provides real-world evidence that implementing a combination of proven HIV prevention measures across communities can substantially reduce new HIV infections ...

Research on HIV viral load urges updates to WHO therapy guidelines

November 24, 2017
A large cohort study in South Africa has revealed that that low-level viraemia (LLV) in HIV-positive patients who are receiving antiretroviral treatment (ART) is an important risk factor for treatment failure.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.