Total retinal blood flow lower in diabetic macular edema

February 13, 2017

(HealthDay)—Total retinal blood flow (TRBF) is significantly lower in eyes of patients with diabetic macular edema (DME), according to a study published online Feb. 9 in JAMA Ophthalmology.

ByungKun Lee, from the Massachusetts Institute of Technology in Cambridge, and colleagues conducted a cross-sectional study involving 41 eyes with (DR) from 31 with diabetes, 20 eyes without DR from 11 patients with diabetes, and 16 eyes from 12 healthy age-matched controls. The authors examined TRBF using en face Doppler optical coherence tomography (OCT) raster scans.

The researchers found that the mean TRBF was 28.0, 48.8, and 40.1 µL/min in the eyes with DME, in the eyes with DR without DME, and in age-matched healthy eyes, respectively. There was no difference in TRBF for eyes with DME that were treated and eyes with DME that were not treated. Regardless of DR severity, the TRBF was consistently low in eyes with DME. The range of TRBF varied from 31.1 to 75.0 µL/min in eyes with moderate non-proliferative DR but without DME.

"High-speed en face Doppler OCT can measure TRBF in healthy and diabetic eyes," the authors write. "Further longitudinal studies of TRBF in eyes with DR would be helpful to determine whether reduced TRBF is a risk factor for DME."

Several authors disclosed financial ties to the biopharmaceutical and medical technology industries.

Explore further: Higher AlphaB-crystallin levels linked to diabetic retinopathy

More information: Full Text (subscription or payment may be required)

Related Stories

Higher AlphaB-crystallin levels linked to diabetic retinopathy

December 21, 2016
(HealthDay)—Vitreous levels of alphaB-crystallin are significantly higher in eyes of patients with proliferative diabetic retinopathy (PDR) compared to the eyes of controls without diabetes, according to a study published ...

Pilocarpine expands schlemm canal in healthy eyes, glaucoma

June 25, 2016
(HealthDay)—Pilocarpine expands the Schlemm canal in eyes with and without glaucoma, according to a study published online June 23 in JAMA Ophthalmology.

Aflibercept rescues vision after laser for diabetic macular edema

December 29, 2016
(HealthDay)—For eyes experiencing substantial visual loss after macular laser photocoagulation treatment for diabetic macular edema (DME), intravitreal aflibercept improves visual and anatomic outcomes, according to a study ...

Prevalence of diabetic macular edema varies by test

January 5, 2016
(HealthDay)—Diabetic macular edema (DME) is more often diagnosed using monocular fundus photography than optical coherence tomography (OCT) central subfield thickness (CST), according to a study published online Dec. 30 ...

Microaneurysm turnover IDs macular edema development

January 8, 2013
(HealthDay)—Microaneurysm (MA) turnover independently predicts the development of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR), according to a study published ...

Recommended for you

A bit of dark chocolate might sweeten your vision

April 26, 2018
It may not replace prescription glasses, but a few bites of dark chocolate might offer a slight and temporary bump up in vision quality, new research suggests.

Fighting diabetic blindness: Researchers develop new target to study potential treatments

April 25, 2018
Diabetic retinopathy is a retinal microvascular disease that often causes blindness in adults who have had diabetes mellitus for 10 years or more. Estimates are that 600 million people will have some sort of diabetic retinopathy ...

FDA approves contact lenses that shade the sun

April 13, 2018
The lives of contact lens wearers just got a whole lot easier.

New glaucoma treatment could ease symptoms while you sleep

April 11, 2018
Eye drops developed by UBC researchers could one day treat glaucoma while you sleep - helping to heal a condition that is one of the leading causes of blindness around the world.

Researchers test stem cell-based retinal implant for common cause of vision loss

April 4, 2018
Physicians and researchers at the USC Roski Eye Institute have collaborated with other California institutions to show that a first-in-kind stem cell-based retinal implant is feasible for use in people with advanced dry age-related ...

Post-Ebola cataract surgery can safely restore vision

April 4, 2018
Cataract surgery can be safely performed on Ebola virus disease survivors with impaired vision, Emory Eye Center ophthalmologists and 40 colleagues around the world report.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.