Total retinal blood flow lower in diabetic macular edema

February 13, 2017

(HealthDay)—Total retinal blood flow (TRBF) is significantly lower in eyes of patients with diabetic macular edema (DME), according to a study published online Feb. 9 in JAMA Ophthalmology.

ByungKun Lee, from the Massachusetts Institute of Technology in Cambridge, and colleagues conducted a cross-sectional study involving 41 eyes with (DR) from 31 with diabetes, 20 eyes without DR from 11 patients with diabetes, and 16 eyes from 12 healthy age-matched controls. The authors examined TRBF using en face Doppler optical coherence tomography (OCT) raster scans.

The researchers found that the mean TRBF was 28.0, 48.8, and 40.1 µL/min in the eyes with DME, in the eyes with DR without DME, and in age-matched healthy eyes, respectively. There was no difference in TRBF for eyes with DME that were treated and eyes with DME that were not treated. Regardless of DR severity, the TRBF was consistently low in eyes with DME. The range of TRBF varied from 31.1 to 75.0 µL/min in eyes with moderate non-proliferative DR but without DME.

"High-speed en face Doppler OCT can measure TRBF in healthy and diabetic eyes," the authors write. "Further longitudinal studies of TRBF in eyes with DR would be helpful to determine whether reduced TRBF is a risk factor for DME."

Several authors disclosed financial ties to the biopharmaceutical and medical technology industries.

Explore further: Higher AlphaB-crystallin levels linked to diabetic retinopathy

More information: Full Text (subscription or payment may be required)

Related Stories

Higher AlphaB-crystallin levels linked to diabetic retinopathy

December 21, 2016
(HealthDay)—Vitreous levels of alphaB-crystallin are significantly higher in eyes of patients with proliferative diabetic retinopathy (PDR) compared to the eyes of controls without diabetes, according to a study published ...

Pilocarpine expands schlemm canal in healthy eyes, glaucoma

June 25, 2016
(HealthDay)—Pilocarpine expands the Schlemm canal in eyes with and without glaucoma, according to a study published online June 23 in JAMA Ophthalmology.

Aflibercept rescues vision after laser for diabetic macular edema

December 29, 2016
(HealthDay)—For eyes experiencing substantial visual loss after macular laser photocoagulation treatment for diabetic macular edema (DME), intravitreal aflibercept improves visual and anatomic outcomes, according to a study ...

Prevalence of diabetic macular edema varies by test

January 5, 2016
(HealthDay)—Diabetic macular edema (DME) is more often diagnosed using monocular fundus photography than optical coherence tomography (OCT) central subfield thickness (CST), according to a study published online Dec. 30 ...

Microaneurysm turnover IDs macular edema development

January 8, 2013
(HealthDay)—Microaneurysm (MA) turnover independently predicts the development of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR), according to a study published ...

Recommended for you

Researchers identify key compounds to resolve abnormal vascular growth in AMD

August 21, 2017
A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers. ...

World's blind population to soar: study

August 3, 2017
The world's blind will increase threefold from about 36 million today to 115 million in 2050 as populations expand and individuals grow ever older, researchers said Thursday.

Simulations signal early success for fractal-based retinal implants

July 27, 2017
Computer simulations of electrical charges sent to retinal implants based on fractal geometry have University of Oregon researchers moving forward with their eyes focused on biological testing.

Scientists regenerate retinal cells in mice

July 26, 2017
Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.

Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina

July 24, 2017
A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina—the sensory tissue at the back of the eye—using gene-editing ...

Too little vitamin D may hinder recovery of injured corneas

July 24, 2017
Injury or disease in combination with too little vitamin D can be bad for the window to your eyes.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.