Repeated eye injections for age-related macular degeneration associated with increased risk for glaucoma

March 16, 2017, The JAMA Network Journals

Patients with age-related macular degeneration who received seven or more eye injections of the drug bevacizumab annually had a higher risk of having glaucoma surgery, according to a study published online by JAMA Ophthalmology.

The advent of intravitreous (in the vitreous, the fluid behind the lens in the eye) anti-vascular endothelial growth factor (VEGF) injections to treat common causes of vision loss, such as exudative (wet) age-related macular degeneration (AMD) and has improved visual outcomes for many patients. Intravitreous injections of anti-VEGF agents may increase the risk of elevated intraocular pressure (IOP); however, the risk of developing moderate to advanced glaucoma requiring has been unclear.

Brennan D. Eadie, M.D., Ph.D., of the University of British Columbia, Vancouver, and colleagues conducted a study that included patients who had received intravitreous bevacizumab injections for exudative . Cases were identified using glaucoma surgical codes for various procedures. For each case, 10 controls were identified; the number of intravitreous bevacizumab injections received per year was determined for both cases and controls.

Seventy-four cases of glaucoma surgery and 740 controls were identified. The researchers found that seven or more injections were associated with a significantly higher risk of glaucoma surgery.

"Clinicians should be aware of the potential association of repeated, recent intravitreous anti-VEGF injections for diseases, such as exudative AMD, with subsequent need for glaucoma surgery," the authors write.

Explore further: Topical dorzolamide-timolol beneficial in neovascular AMD

More information: JAMA Ophthalmol. Published online March 16, 2017.DOI: 10.1001/jamaophthalmol.2017.0059

Related Stories

Topical dorzolamide-timolol beneficial in neovascular AMD

February 26, 2016
(HealthDay)—Topical dorzolamide hydrochloride-timolol appears to reduce central subfield thickness and subretinal fluid in eyes of patients with neovascular age-related macular degeneration (AMD) and incomplete response ...

Mayo Clinic detective work shows possible side effect in macular degeneration drug

October 24, 2011
Two major drug trials conclude there was little risk from a drug aimed at age-related macular degeneration. Yet a Mayo Clinic ophthalmologist began to note something concerning in some of her patients: an increase in pressure ...

Bevacizumab, triamcinolone up outcome after cataract surgery

March 9, 2016
(HealthDay)—For patients undergoing cataract surgery, both bevacizumab and triamcinolone administered at the time of surgery correlate with improvements in visual acuity (VA), but only triamcinolone is associated with sustained ...

New study pinpoints biochemical mechanism underlying fibrosis following glaucoma surgery

May 17, 2013
The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial ...

Moderate interobserver agreement for glaucoma software

March 7, 2017
(HealthDay)—There is moderate interobserver agreement among glaucoma specialists using two glaucoma progression software packages, according to a study published online Feb. 23 in JAMA Ophthalmology.

Experimental drug shows promise for sight-stealing eye condition

January 19, 2017
An experimental drug may one day make treatment simpler for patients suffering from vision-threatening age-related macular degeneration, researchers say.

Recommended for you

Outbreak of preventable eye infection in contact lens wearers

September 21, 2018
A new outbreak of a rare but preventable eye infection that can cause blindness, has been identified in contact lens wearers in a new study led by UCL and Moorfields Eye Hospital researchers.

Newly formed blood vessels may contribute to eye disease

September 14, 2018
Newly formed blood vessels may be cracks in the barrier between the bloodstream and the eye, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.

Eye disease can cause blindness, and it's on the rise

August 29, 2018
A new study into recent cases of ocular syphilis warns increasing numbers of people are at risk of permanent damage to their vision.

INSiGHT identifies unique retinal regulatory genes

August 28, 2018
Vision begins in the retina, a light-sensing neural network in the eye that is critical for our ability observe the world around us. Researches at Baylor College of Medicine, Texas Children's Hospital and the Hospital for ...

Alzheimer's one day may be predicted during eye exam

August 23, 2018
It may be possible in the future to screen patients for Alzheimer's disease using an eye exam.

Researchers find potential new gene therapy for blinding disease

August 20, 2018
The last year has seen milestones in the gene therapy field, with FDA approvals to treat cancer and an inherited blinding disorder. New findings from a team led by University of Pennsylvania vision scientists, who have in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.