The secret to combating pancreatic cancer may lie in suppression of a common protein

The secret to combating pancreatic cancer may lie in suppression of a common protein
The green line represents male mice with pancreatic cancer-causing genes and expressing half the normal amount of GRP78 protein. These mice survived longer than those that had pancreatic cancer-causing genes, but normal levels of GRP78, represented by the red line. Credit: Amy Lee, PhD, Keck School of Medicine

New research from the Keck School of Medicine of the University of Southern California (USC) shows new promise in the fight against one of the most lethal forms of cancer. Studies in mice with a mutation present in 90 percent of pancreatic cancer patients (the KRAS mutation) indicate that expressing only half the amount of the glucose-regulated protein GRP78 is enough to halt the earliest stage of pancreatic cancer development.

The study, funded in part by the National Institutes of Health, suggests that because the is required for "switching" healthy pancreatic that produce enzymes to digest food into potentially cancerous cells, reducing the amount of this protein delays pancreatic development and prolongs survival. The study, published online on May 16 in the Proceedings of the National Academy of Sciences, is the first to establish the pivotal role of the protein in pancreatic cancer.

"Cancer cells are addicted to high levels of GRP78 for cancer development and growth. Our hope is that partially reducing or inactivating the protein by therapeutic agents could one day be an effective complementary therapy for pancreatic cancer and other cancers, while sparing other healthy organs," said Amy Lee, PhD, professor of biochemistry and molecular medicine at the Keck School and the Judy and Larry Freeman Chair in Basic Science Research at the USC Norris Comprehensive Cancer Center.

Lee, who was the first scientist to clone human GRP78, has since dedicated much of her research to investigating the protein's role in cancer progression and treatment. For her scientific contributions, Lee was honored by a MERIT award from the National Cancer Institute and elected as Fellow of the American Association for the Advancement of Science.

"As developing drugs directly targeting the KRAS genetic mutation has been challenging, we are thrilled these findings indicate that we can attack KRAS-driven pancreatic cancer through an entirely new method," Lee said.

GRP78 is a stress-inducible protein that folds newly synthesized proteins and performs quality control in the endoplasmic reticulum (an essential component of human cells). During stress, a fraction of GRP78 is shipped out to the cell surface to perform additional growth and survival functions. Cancer cells, particularly those that survive treatment, typically undergo more stress than healthy cells, resulting in increased levels of GRP78 to help the survive, grow and develop therapeutic resistance.

A number of studies across cancer types have shown a relationship between highly elevated levels of the protein and increased risk for cancer recurrence or decreased survival. With GRP78 emerging as an attractive anti-cancer target, there is active development of potential treatments that can inhibit GRP78 activity or expression, including some that are in early-phase clinical trials with promising results. Certain food and herbs, including green tea and soy, contain natural compounds that can suppress the protein, Lee said.

Patients and physicians alike are eager for more effective treatments for pancreatic cancer, as it is among the deadliest forms of cancer. According to the American Cancer Society, more than 53,600 people will be diagnosed with pancreatic cancer this year, and more than 43,000 people will die from the disease. The five-year survival rate for early stage cancer is only 12 percent, compared to 100 percent for breast cancer and prostate cancer and 92 percent for colon cancer.

"Translating any basic science discovery into clinical practice is a long process that requires substantial resources," Lee said. "But given the notorious difficulties of treating KRAS-mutation related cancers, particularly in a disease as devastating as , this research provides hope and a novel approach. I am excited to put our theories to test in the clinical setting."

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More information: Jieli Shen et al, GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant-driven pancreatic tumorigenesis in mice, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1616060114
Citation: The secret to combating pancreatic cancer may lie in suppression of a common protein (2017, May 22) retrieved 9 August 2020 from
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