Review links conjugated linoleic acid supplementation to CRP

June 24, 2017

(HealthDay)—Conjugated linoleic acid (CLA) supplementation is associated with an increase in serum C-reactive protein (CRP) concentration, according to a review and meta-analysis published online May 29 in Cardiovascular Therapeutics.

Mohsen Mazidi, Ph.D., from the Chinese Academy of Sciences in Beijing, and colleagues conducted a systematic review and meta-analysis to examine the impact of CLA supplementation on serum CRP. Data were included from 14 studies.

The researchers found that following supplementation with CLAs there was a significant increase in serum CRP concentrations (weighted mean difference, 0.63 mg/dL; 95 percent confidence interval, 0.13 to 1.13; heterogeneity P = 0.026); these findings were robust in sensitivity analyses. The changes in serum CRP levels were found to be independent of CLA supplementation dosage (slope, −0.02; 95 percent confidence interval, −0.10 to 0.12; P = 0.889) or follow-up duration (slope, 0.271; 95 percent confidence interval, −0.05 to 0.59; P = 0.098).

"This meta-analysis suggests that CLA supplementation is associated with an increase in plasma CRP concentrations and a reduction in adiponectin concentrations, which indicates that CLA have a pro-inflammatory effect," the authors write.

Explore further: Valproic acid concentration drops with ketogenic diet

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Valproic acid concentration drops with ketogenic diet

June 22, 2017
(HealthDay)—For patients with epilepsy, anti-epileptic drug serum concentrations remain stable during the ketogenic diet (KD), apart from those of valproic acid, according to a study published online June 18 in the Journal ...

Probiotic supplements may help prevent infantile eczema

July 29, 2015
(HealthDay)—Probiotic supplementation in pregnancy and early infancy can prevent infantile eczema, according to a review and meta-analysis published online July 21 in Allergy.

Relapse risk up with low vitamin D levels in ulcerative colitis

February 1, 2017
(HealthDay)—For patients with ulcerative colitis (UC), serum vitamin D levels ≤35 ng/mL are associated with increased risk of clinical relapse, according to a study published in the February issue of Clinical Gastroenterology ...

Fish oil supplementation doesn't cut inflammatory markers

November 2, 2015
(HealthDay)—For healthy adults, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation does not reduce common markers of systemic inflammation, according to a study published online Oct. 26 in the Journal ...

Low serum levels of DHEAS predict fractures in older men

March 22, 2017
(HealthDay)—For older men, low serum levels of the adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are a risk marker for fractures, according to a study published online March 9 in the Journal ...

Meta-analysis confirms serum 25(OH)D, mortality link

June 20, 2014
(HealthDay)—Serum 25-hydroxyvitamin (25[OH]D) levels are associated with all-cause and cardiovascular mortality, according to a meta-analysis published online June 17 in BMJ.

Recommended for you

Gut protein mutations shield against spikes in glucose

November 20, 2018
Why is it that, despite consuming the same number of calories, sodium and sugar, some people face little risk of diabetes or obesity while others are at higher risk? A new study by investigators at Brigham and Women's Hospital ...

Proteins cooperate to break up energy structures in oxygen starved heart cells

November 19, 2018
During a heart attack, the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell's powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart ...

Bullying and violence at work increases the risk of cardiovascular disease

November 19, 2018
People who are bullied at work or experience violence at work are at higher risk of heart and brain blood vessel problems, including heart attacks and stroke, according to the largest prospective study to investigate the ...

Genetic analysis links obesity with diabetes, coronary artery disease

November 16, 2018
A Cleveland Clinic genetic analysis has found that obesity itself, not just the adverse health effects associated with it, significantly increases the risk of Type 2 diabetes and coronary artery disease. The paper was published ...

Non-coding genetic variant could improve key vascular functions

November 15, 2018
Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 ...

Study of two tribes sheds light on role of Western-influenced diet in blood pressure

November 14, 2018
A South American tribe living in near-total isolation with no Western dietary influences showed no increase in average blood pressure from age one to age 60, according to a study led by researchers at Johns Hopkins Bloomberg ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.