Researchers find new genes link to arthritis in bone marrow lesions

July 18, 2017

Researchers have found a pattern of genes which is characteristic of osteoarthritis and may be a step towards better treatments for this condition.

Pain is a major problem for people worldwide and arthritis is a major cause of , especially in the elderly. Bone marrow lesions are parts of the bone which are linked to in osteoarthritis.

The genes found are involved in new nerve formation, pain sensitisation, bone and cartilage renewal.

The lesions appear due to increased pressure on the joint and can be seen on MRI scans, but have never been investigated in this way before.

Lead author Dr Nidhi Sofat, Consultant Rheumatologist of St George's, University of London, said: "Our study has found that a number of new genes not previously linked to arthritis are found in bone marrow lesions and may be driving the pain and stiffness that patients suffer from . This may help us to develop ways of understanding the disease and combat it in the future.

"We carried out the first gene expression study of bone marrow lesions ever done worldwide.''

"The cause of pain in is not fully understood so any clues we come across is a step nearer to developing new improved treatments."

The findings were published in the Annals of Rheumatic Diseases.

Explore further: Glucosamine fails to prevent deterioration of knee cartilage, decrease pain

More information: Anasuya Kuttapitiya et al. Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation, Annals of the Rheumatic Diseases (2017). DOI: 10.1136/annrheumdis-2017-211396

Related Stories

Glucosamine fails to prevent deterioration of knee cartilage, decrease pain

March 11, 2014
A short-term study found that oral glucosamine supplementation is not associated with a lessening of knee cartilage deterioration among individuals with chronic knee pain. Findings published in Arthritis & Rheumatology, a ...

Bisphosphonates could offer effective pain relief in osteoarthritis, research finds

September 6, 2013
St George's, University of London research has found that a drug normally given to osteoporosis sufferers could provide effective pain relief to patients with knee and hip osteoarthritis.

Bone marrow lesions can help predict rapidly progressing joint disease

January 15, 2016
A new study from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, shows lesions, which can best be seen on MRI scans, could help identify individuals who are more likely to suffer from ...

Noisy knees may be an early sign of knee osteoarthritis

May 4, 2017
A new study using data from the Osteoarthritis Initiative, a multi-center observational study of nearly 3500 participants, indicates that people who hear grating, cracking, or popping sounds in or around their knee joint ...

Study provides insights on optimal treatment of Paget's disease of bone

February 8, 2017
In a study of patients with Paget's disease of bone—a common skeletal disorder that can lead to bone deformity, fractures, osteoarthritis, and bone pain—long-term intensive bisphosphonate therapy conferred no clinical ...

New early warning sign of knee osteoarthritis

November 23, 2015
People who are at higher risk to develop knee osteoarthritis (OA) from being overweight or having injured their knee in the past may have normal x-rays, but worsening lesions or damage appearing on their MRIs predicts a significantly ...

Recommended for you

Prototype equipment can detect rheumatoid arthritis

September 28, 2017
According to a first clinical study published in the scientific journal Photoacoustics, the University of Twente and various European partners have designed a device that shows the difference between healthy fingers and arthritic ...

Improving the recognition of anxiety and depression in rheumatoid arthritis

August 28, 2017
A study conducted by Keele University shows that patients with rheumatoid arthritis who are also suffering with anxiety or depression may avoid talking to their GP about their mental health symptoms.

How you think about your arthritis makes a difference

August 24, 2017
(HealthDay)—How well you cope with knee arthritis depends a lot on your mental outlook, a new study suggests.

Treating arthritis with algae

August 23, 2017
Researchers at ETH Zurich, Empa and the Norwegian research institute SINTEF are pursuing a new approach to treating arthritis. This is based on a polysaccharide, a long-chain sugar molecule, originating from brown algae. ...

Study shows prevalence of knee osteoarthritis has doubled since World War II

August 14, 2017
The average American today is twice as likely to be diagnosed with knee osteoarthritis than in the years before World War II, Harvard scientists say, but that increase can't be blamed on the reasons most might think.

Researchers find arthritis drug could treat blood cancer patients

August 3, 2017
Blood cancer sufferers could be treated with a simple arthritis drug, scientists at the University of Sheffield have discovered.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.