Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
The left and right show xenograft tumors of parental cells and PTPRZ knockdown cells, respectively. Credit: NIBB

Glioblastoma is a malignant brain tumor with high mortality. Cancer stem cells are thought to be crucial for tumor initiation and its recurrence after standard therapy with radiation and temozolomide (TMZ) chemotherapy. Protein tyrosine phosphatase receptor type Z (PTPRZ) is an enzyme that is highly expressed in glioblastoma, especially in cancer stem cells.

The research group of Professor Masaharu Noda and Researcher Akihiro Fujikawa of the National Institute for Basic Biology (NIBB) showed that the enzymatic activity of PTPRZ is requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells.

PTPRZ knockdown strongly inhibited tumor growth of C6 glioblastoma cells in a mouse xenograft model. In addition, the research team discovered NAZ2329, an allosteric inhibitor of PTPRZ, efficiently suppressed stem cell-like properties of in culture, and tumor growth in C6 glioblastoma xenografts. These results indicate that pharmacological inhibition of PTPRZ is a promising strategy for the treatment of malignant gliomas.

  • Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
    NAZ2329 bound to an allosteric pocket close to the active center of PTPRZ. Credit: NIBB, ASUBIO Pharma
  • Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
    Tumor growth was inhibited more effectively by co-treatment with NAZ2329 and TMZ than by the individual treatments. Credit: NIBB

Explore further

Using a microRNA to shift the makeup of glioblastoma subtypes

More information: Akihiro Fujikawa et al, Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells, Scientific Reports (2017). DOI: 10.1038/s41598-017-05931-8
Journal information: Scientific Reports

Provided by National Institutes of Natural Sciences
Citation: Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma (2017, July 19) retrieved 23 July 2019 from https://medicalxpress.com/news/2017-07-identification-ptprz-drug-cancer-stem.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
0 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more