Morphine effects similar to placebo in rheumatoid arthritis

July 27, 2017

(HealthDay)—For patients with chronic fatigue syndrome (CFS)/fibromyalgia (FM) or rheumatoid arthritis (RA), morphine has anti-hyperalgesic effects comparable to placebo, according to a study published online July 19 in PAIN Practice.

Linda Hermans, P.T., from Ghent University in Belgium, and colleagues conducted a randomized, double-blind, placebo-controlled trial. Ten patients with CFS/FM, 11 with RA, and 20 controls were randomized to experimental (10 mg /0.2 mg/mL naloxone) and placebo groups.

The researchers found that at baseline, compared with controls, patients with CFS/FM and RA had lower deep tissue pressure and higher temporal summation. In both patient groups, morphine had a positive effect only on pressure pain thresholds (PPTs); PPTs increased after placebo, but no effects on other pain parameters were objectified. Neither naloxone nor nocebo had significant effects on PPT, deep tissue pain, temporal summation, or conditioned pain modulation (CPM) in the control group.

"The effect of morphine in central sensitization patients appears limited and could have more effect on a peripheral level. Nevertheless, the morphine effect on experimental pain measures was comparable to the of placebo," the authors write. "Naloxone did not significantly affect nociceptive modulation in the healthy participants. These results suggest that temporal summation and conditioned pain modulation are not primarily mediated by opioid mechanisms."

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Can staying active help to prevent chronic pain? Physical activity affects pain modulation in older adults

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Can staying active help to prevent chronic pain? Physical activity affects pain modulation in older adults

February 24, 2017
Older adults with higher levels of physical activity have pain modulation patterns that might help lower their risk of developing chronic pain, reports a study in PAIN, the official publication of the International Association ...

Lumbopelvic stabilization training therapeutic for LBP

January 5, 2017
(HealthDay)—For patients with chronic nonspecific low back pain conditions, lumbopelvic stabilization training (LPST) has a therapeutic effect on pain modulation, according to a study published online Jan. 2 in Pain Practice.

Pregabalin significantly improves neuropathic pain

September 9, 2016
(HealthDay)—Pregabalin significantly improves neuropathic pain, irrespective of the time since pain onset, according to a study published online Sept. 2 in Pain Practice.

Gabapentin doesn't cut use of morphine post-knee arthroplasty

November 27, 2013
(HealthDay)—The addition of gabapentin to patient-controlled analgesia (PCA) protocol does not reduce morphine consumption, pain, or opioid-related side effects in patients undergoing total knee arthroplasty, according ...

New naloxone capsule safe for opioid-induced constipation

July 1, 2015
(HealthDay)—A new naloxone sustained release (NSR) capsule appears to be safe and efficacious for opioid-induced constipation (OIC), according to a study published online June 24 in Pain Medicine.

Study assesses sublingual fentanyl vs morphine for CA pain

January 26, 2017
(HealthDay)—For patients with severe cancer pain episodes, fentanyl sublingual tablets (FST) offer analgesia with modest to moderate increased risk of lower efficacy compared with subcutaneous morphine (SCM), according ...

Recommended for you

Researchers find arthritis drug could treat blood cancer patients

August 3, 2017
Blood cancer sufferers could be treated with a simple arthritis drug, scientists at the University of Sheffield have discovered.

Fluid in the knee holds clues for why osteoarthritis is more common in females

June 26, 2017
Researchers have more evidence that males and females are different, this time in the fluid that helps protect the cartilage in their knee joints.

Biologics before triple therapy not cost effective for rheumatoid arthritis

May 29, 2017
Stepping up to biologic therapy when methotrexate monotherapy fails offers minimal incremental benefit over using a combination of drugs known as triple therapy, yet incurs large costs for treating rheumatoid arthritis (RA). ...

Drug for refractory psoriatic arthritis shows promise in clinical trial

May 24, 2017
In a pivotal phase-3 clinical trial led by a Stanford University School of Medicine investigator, patients with psoriatic arthritis for whom standard-of-care pharmaceutical treatments have provided no lasting relief experienced ...

Cross-species links identified for osteoarthritis

May 17, 2017
New research from the University of Liverpool, published today in the journal npj Systems Biology and Applications, has identified 'cell messages' that could help identify the early stages of osteoarthritis (OA).

Osteoarthritis could be prevented with good diet and exercise

May 12, 2017
Osteoarthritis can potentially be prevented with a good diet and regular exercise, a new expert review published in the Nature Reviews Rheumatology reports.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.