Paris spotlight on latest in AIDS science

Today's research is about finding ways to keep HIV dormant with as few drugs and side-effects as possible
Today's research is about finding ways to keep HIV dormant with as few drugs and side-effects as possible

Some 6,000 HIV experts gather in Paris from Sunday to report advances in AIDS science as fading hopes of finding a cure push research into new fields.

In their 36-year battle, researchers have always come up short against the ' guerrilla tactics—hiding out in human cells and playing dead only to reemerge and attack as soon as treatment is stopped.

Today's research is about finding ways to keep the virus dormant with as few drugs and side-effects as possible.

And, of course, better ways to prevent infection in the first place.

"Eradicating the virus from someone, where you completely get rid of every single viral particle, is very difficult, if not impossible," said AIDS expert Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID)—a branch of the US government's National Institutes of Health (NIH).

"So what we're focusing more on is... called an ART-free remission," he told AFP—using the acronym for anti-retroviral therapy.

The new buzzword is "functional cure".

Unlike a traditional cure, where the virus is eradicated, the patient would still have HIV in their system.

But the virus would be so weakened that it cannot replicate, or spread to sexual partners, for a prolonged period of time—researchers hope permanently—without the need for daily drugs.

Though much improved since their revolutionary arrival in the 1990s, anti-retrovirals have side-effects which can include diarrhoea, skin rashes, nausea, insomnia and headaches.

And providing a lifelong supply to millions of people is a costly affair.

The World Health Organization (WHO) recommends ART for every one of the 36.7 million people living with HIV today. By 2016, some 19.5 million were getting it, according to UNAIDS.

'Almost everybody rebounds'

The cost of treatment, in poor countries, ranges from $85 (74 euros) per person per year, to over $1,200 in cases where the first line of available drugs fail to work.

Worried specialists say the need to switch treatment is now more common as the virus becomes resistant to first-choice medication.

"We cannot afford to keep funding an epidemic of this proportion," said Linda-Gail Bekker, HIV vaccine researcher and president of the International AIDS Society hosting the conference in Paris, where lab scientists in 1983 identified the discovered the virus that causes AIDS.

"The long-term plan is if we can reduce our treatment pool... through remission, then that will be fantastic," she added.

Among the many promising, but as-yet-elusive strategies being probed, is getting people on medication as soon as possible after infection—seemingly the best hope, especially in newborns, for long-term remission.

The worldwide AIDS epidemic
Data on the number of people affected by HIV in selected parts of the world in 2016

Other hopeful possibilities include injections of virus-fighting antibodies, boosting the patient's own immune system with a so-called therapeutic vaccine, or long-acting injectable forms of ARV, experts say.

Only a few people have achieved drug-free remission to date.

They include a group of 14 patients started on drugs in a French trial within 10 weeks of infection, who were able to stop after three years and have stayed healthy for several years since then.

Two years ago, a French teenager was reported to have been in remission for 12 years after stopping her medication.

In the United States, the so-called Mississippi Baby was in remission for 27 months after being given ART for the first 18 months of life, but the virus rebounded in a major let-down for researchers.

"People are realising that no matter what you do, for the most part.... when you stop therapy almost everybody rebounds," said Fauci.

HIV is not over

Another research priority is prevention.

As work on a vaccine—the holy grail—continues furiously in several countries simultaneously, much research is dedicated to the more immediate challenge of reducing infection through sex.

A far cry from the ABC (Abstain, Be faithful, Condomise) message of the 1990s, the new angle of attack includes such interventions as drug-doused vaginal rings and male circumcision to limit virus spread.

And then there is PrEP—short for pre-exposure prophylaxis, which involves healthy people taking ARVs as protection.

It is an expensive option, but early trials have shown it does lower the risk.

The July 23-26 conference happens amid concerns that funding for HIV research and treatment programmes may be under threat.

US President Donald Trump has proposed to cut the 2018 NIH budget, for example, and not to increase the life-saving PEPFAR AIDS relief fund.

"Our extraordinary scientific progress against HIV and our ability to address all of the scientific challenges still before us are threatened by a weakening resolve to fund HIV science," said a conference statement.

"HIV is not over," added Bekker.

With 1.8 million new infections last year, bringing to nearly 40 million the number of people who will need life-long treatment, "there is still an epidemic of extraordinary proportions," she said.

"If we take our eye off this ball, we will find ourselves backsliding in scary ways."

Five key numbers on AIDS

Someone is infected with the AIDS virus every 17 seconds in the world, and the disease has killed the equivalent of the population of Canada, figures released Thursday by UNAIDS show.

Here is a numerical snapshot of the disease.

17 seconds

Roughly 1.8 million people worldwide contracted the AIDS virus in 2016. That figure breaks down to about one infection by the human immunodeficiency virus (HIV) that causes AIDS every 17 seconds on average, or almost 5,000 per day.

Two-thirds of new cases in Africa

Since 2010, the rate of infection among adults has decreased slowly from 1.9 million then to 1.7 million per year in 2016. Two-thirds of new cases occur in Africa.

Children's cases cut almost by half

New infections among children have fallen sharply meanwhile, and since 2010 they have been cut almost by half, from 300,000 to 160,000 in 2016.

A key factor has been detection among pregnant women in Africa, followed by treatment with anti retroviral drugs that protect their baby.

Nearing 40 million with HIV

Today, close to 40 million people live with the virus. UNAIDS put their number last year at 36.7 million.

The number continues to increase however owing to continued transmission and increased access to anti-retroviral drugs in developing countries that has raised the survival rate of HIV-positive people.

Deaths halved

AIDS-related deaths have declined by almost 50 percent since a peak of 1.9 million in 2005, to 1.0 million in 2016.

Almost 20 million people now have access to effective treatment when followed regularly.

An estimated 36 million people have died since the AIDS epidemic erupted in 1981 according to the WHO, roughly equivalent to Canada's population.

Explore further

As tide turns, AIDS claimed 1 million lives in 2016: UN (Update)

© 2017 AFP

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Jul 21, 2017
What were the results of the world congress on mycoplasmas? Also in Paris?
Remember that most of our 'treatment' for most diseases is a course of two different medications which is what they are planning for AIDS. So its more of the same.
Recall that polio also produced 'polio renamed meningitis.'
I am thinking this is about being able to sell a 'cure' to the world like the polio shot forced on every nation. Convince everyone its a global problem then force on the world a 'cure.'
What if O2 shortage is the base of most disease? I look at global maps of CO and CO2 coverage and am aghast at the CO blanket in middle America from the Great Lakes to the Gulf. Why are just the heavily populated cities of the East coast experiencing CO coverage when you would expect all the east coast to be? Because the CO is from coal burners and the East coast still --luckily--uses hydro.

Jul 21, 2017
Look at Africa. we're told that the individual farmers are responsible for the huge coverage of CO. From the Atlantic ocean up to the Congo. I read up on Zaire and Angola in WIKI and I see that the civil wars have made millions homeless. Even recovered Angola from not only independence but a 25 year civil war has yet to be able to feed more than half of its people. It imports grain. So why the massive CO coverage? Because western interests have monopolized its gas and oil fields and the offshore rigs are saturating the land to the west. And we pretend not to see.

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