Early drivers of gastric cancer

August 9, 2017 by Leigh Macmillan, Vanderbilt University

Gastric cancer – a leading cause of cancer-related deaths worldwide – is commonly diagnosed at a late stage when most patients have a poor prognosis.

Wael El-Rifai, M.D., Ph.D., and colleagues are exploring the molecular alterations that drive gastric carcinogenesis, to improve early detection, treatment and prevention. They previously showed that knocking out (eliminating) the gene Tff1 in mice induces that include low- and high-grade dysplasia and adenocarcinomas.

Now, they have investigated in low-grade dysplastic lesions and normal stomach tissue from mice and in gastric cancer and normal stomach tissue from humans. Using bioinformatics approaches, they identified transcription (gene expression) networks that were consistently deregulated in both mouse and human lesions.

The findings, reported in the July issue of Genes, Chromosomes and Cancer, suggest that activation of MYC, STAT3, and beta-catenin transcription networks could be an early molecular step in gastric tumorigenesis. The findings also support using the Tff1-knockout mouse model for in vivo studies of molecular mechanisms in .

Explore further: First roadmap of stomach cancer super-enhancers paves the way for new treatments

More information: Zheng Chen et al. Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia, Genes, Chromosomes and Cancer (2017). DOI: 10.1002/gcc.22456

Related Stories

First roadmap of stomach cancer super-enhancers paves the way for new treatments

July 26, 2017
A*STAR researchers have homed in on a potential new way to diagnose and treat stomach cancer, through the mapping of an unprecedented catalog of almost 3,800 super-enhancers from stomach cancer tumor cells.

Differences in subtypes of gastric cancer may determine prognosis and response to treatment

July 26, 2017
Molecular classification of the four distinct subtypes of gastric cancer could potentially shape tailored treatment options by helping to predict survival outcomes and patients' response to chemotherapy.

Role of innervation explored in gastric tumorigenesis

August 21, 2014
(HealthDay)—Vagal innervation is involved in gastric tumorigenesis, according to an experimental study published in the Aug. 20 issue of Science Translational Medicine.

miR-7 suppresses stomach cancer

August 10, 2015
A study in The Journal of Cell Biology reveals that the microRNA miR-7 suppresses gastric (stomach) cancer by inhibiting a key signaling pathway, and that this protective mechanism is compromised by the cancer-causing bacterium ...

Ironing out the link between H. pylori infection and gastric cancer

December 21, 2012
H. pylori frequently causes gastric ulcers and is also one of the greatest risk factors for gastric cancer. H. pylori infection is also associated with another gastric cancer risk factor, iron deficiency.

Recommended for you

Researchers artificially generate immune cells integral to creating cancer vaccines

August 14, 2018
For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a study published in August in Cell Reports.

Chemicals found in vegetables prevent colon cancer in mice

August 14, 2018
Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows.

Ovarian cancer genetics unravelled

August 14, 2018
Patterns of genetic mutation in ovarian cancer are helping make sense of the disease, and could be used to personalise treatment in future.

Lymphatic vessels unexpectedly promote the spread of cancer metastases

August 14, 2018
Lymphatic vessels actively contribute to the spread of cancer metastases from various organs. This unexpected realisation is the result of a joint study by researchers from ETH Zurich and the University Hospital Zurich as ...

Researchers uncover a major new vulnerability of childhood leukemia

August 14, 2018
Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat. One of these ...

Stress hormone is key factor in failure of immune system to prevent leukemia

August 14, 2018
The human stress hormone cortisol has been identified by scientists at the University of Kent as a key factor when the immune system fails to prevent leukemia taking hold.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.