Graft survival similar for kidneys from octogenarians

Graft survival similar for kidneys from octogenarians

(HealthDay)—Graft survival is similar for recipients of kidneys from >80-year-old donors and donors aged ≤60 years, according to a study published online Aug. 9 in the American Journal of Transplantation.

Piero Ruggenenti, M.D., from the Clinical Research Centre for Rare Diseases Aldo e Cele Daccò in Bergamo, Italy, and colleagues compared for 37 recipients of one or two histologically evaluated kidneys from >80-year-old donors with 198 reference-recipients of nonhistologically evaluated single grafts from ≤60-year-old donors.

The researchers found that two recipients (5.4 percent) and 10 reference-recipients (5.1 percent) required dialysis over a median of 25 months (crude and donor age- and sex-adjusted hazard ratios, 1.55 [95 percent confidence interval, 0.34 to 7.12; P = 0.576] and 1.41 [95 percent confidence interval, 0.1 to 19.54; P = 0.798]). Similar outcomes were confirmed in shared frailty analyses in a 1-to-2 propensity score study comparing recipients with 74 reference-recipients matched by center, year, and donor and recipient sex and age. Over 84-month follow-up, serum creatinine was similar across groups. Recipients had shorter waiting times than reference-recipients and matched reference-recipients (7.5 versus 36 and 40 months, respectively; both P < 0.0001). Similar adverse events were seen across groups.

"Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the -organ pool and faster access to a transplant, without increasing the risk of premature failure," the authors write.

Explore further

Calculator estimates success of kidney transplants with particular donor-recipient pairs

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2017 HealthDay. All rights reserved.

Citation: Graft survival similar for kidneys from octogenarians (2017, August 15) retrieved 24 June 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments