Hyperglycemia may cause caries but not periodontal disease

August 14, 2017

(HealthDay)—For rodents with diabetes, periodontal inflammation may be derived from dental caries rather than periodontal disease (PD), according to a study published online Aug. 9 in Diabetes.

Yutaka Nakahara, from Setsunan University in Osaka, Japan, and colleagues prevented carious inflammation with administration in diabetic animal models to confirm the presence of PD. Tap water alone or with fluoride was given to F344 rats injected with alloxan (type 1 diabetes model) and db/db mice (type 2 diabetes model).

The researchers found that the cariostatic effect of fluoride was seen in the diabetic animal models. In addition to preventing , fluoride treatment attenuated periodontal inflammation. Periodontitis was nonexistent in the periodontal tissue surrounding the normal molars with fluoride treatment; in the teeth that were enveloped with persistent periodontitis, the caries-forming process was clearly observed.

"In conclusion, long-term hyperglycemia naturally induces dental caries but not PD in type 1 and type 2 diabetic rodents," the authors write.

One author disclosed financial ties to Astellas Pharma.

Explore further: Diabetes causes shift in oral microbiome that fosters periodontitis, study finds

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Diabetes causes shift in oral microbiome that fosters periodontitis, study finds

July 12, 2017
A new study led by University of Pennsylvania researchers has found that the oral microbiome is affected by diabetes, causing a shift to increase its pathogenicity. The research, published in the journal Cell Host & Microbe ...

Periodontal disease predicts CAC progression in type 1 diabetes

August 31, 2015
(HealthDay)—In patients with type 1 diabetes, but not those without diabetes, periodontal disease duration is an independent predictor of long-term progression of coronary artery calcium (CAC), according to a study published ...

Effects of composites containing bioactive glasses on demineralized dentin

July 4, 2017
Bacterial plaque causes tooth decay due to acids produced by different bacteria species; this has trigged an intense research activity for the development of novel restorative biomaterials with protective and self-healing ...

Study reveals new link between periodontal and cerebrovascular diseases

July 18, 2016
A new study has revealed a relationship between chronic periodontitis and lacunar infarct, two common diseases in the elderly. Chronic periodontitis is an inflammatory disease of the gums, whereas lacunar infarct is a type ...

Nonsurgical treatment of periodontitis for persons with diabetes does not improve glycemic control

December 17, 2013
For persons with type 2 diabetes and chronic periodontitis, nonsurgical periodontal treatment did not result in improved glycemic control, according to a study appearing in the December 18 issue of JAMA.

Preventing tooth decay in children

April 14, 2017
Applying fluoride varnish to children's teeth is just as effective at preventing tooth decay as the alternative method of sealing teeth and could save the NHS money, concludes a study led by Cardiff University.

Recommended for you

Smoking linked with higher risk of type 2 diabetes

March 15, 2018
The prevalence of diabetes has increased almost 10-fold in China since the early 1980s, with one in 10 adults in China now affected by diabetes. Although adiposity is the major modifiable risk factor for diabetes, other research ...

Toothpaste alone does not prevent dental erosion or hypersensitivity

March 14, 2018
The rising prevalence of dental erosion and dentin hypersensitivity has led to the emergence of more toothpastes that claim to treat these problems. While no such toothpaste existed 20 years ago, today, many such brands are ...

Social support and machine learning are at the core of a student-developed app for people with diabetes

March 14, 2018
Diabetes is the seventh leading cause of death in the U.S., and nearly 10 percent of the population suffers from this chronic disease, according to the Centers for Disease Control and Prevention.

Study: Absence of key protein, TTP, rapidly turns young bones old

March 10, 2018
The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss, according to a new University at Buffalo study.

Toxic proteins and type 2 diabetes

March 9, 2018
Nearly a half-billion people worldwide live with type 2 diabetes. Yet despite the disease's sizeable and increasing impact, its precise causes remain murky. Current scientific thinking points to two key processes: insulin ...

Fiber-fermenting bacteria improve health of type 2 diabetes patients

March 8, 2018
The fight against type 2 diabetes may soon improve thanks to a pioneering high-fiber diet study led by a Rutgers University-New Brunswick professor.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.