Map of oncogenic dependencies for the design of personalized therapeutic approaches

Map of oncogenic dependencies for the design of personalized therapeutic approaches
Credit: Swiss Institute of Bioinformatics

Being able to predict the resistance or sensitivity of a tumour cell to a drug is a key success factor of cancer precision therapy. But such a prediction is made difficult by the fact that genetic alterations in tumours change dynamically over time and are often interdependent, following a pattern that is poorly understood. A recent study led by researchers at the SIB Swiss Institute of Bioinformatics, University of Lausanne and EPFL provides a promising framework to anticipate drug resistance in cancer by predicting the co-occurrence of about 500 known tumour alterations, as well as their response to over 200 common cancer drugs. The research, published in Cancer Cell, showed that while some co-occurrences between genomic alterations confer a resistance to tumour cells against particular drugs, they also make them sensitive to other unexpected drugs.

Cancer is an ever-changing disease that evolves through the emergence and selection of new . In order to match specific drugs to such alterations and predict their response requires an understanding of how alterations depend on each other and co-occur in a tumour.

"If you think of as food items, then cells are not a random pile of products stuck in a fridge, but carefully designed dinner menus in which dishes are combined and flavours matched," says Giovanni Ciriello, Group Leader at SIB and at the University of Lausanne.

A team of researchers, led by Ciriello, was able to study how alterations in a tumour depend on each other and how these dependencies determine cancer evolution in silico. They provide an extensive map of dependencies between ~500 known tumour alterations, and a robust theoretical framework to predict the co-occurrences of such alterations and their anticipated response to over 200 common cancer drugs.

The team showed that some dependencies between genomic alterations could confer to tumour cells a resistance to particular drugs, while at the same time acting as an 'Achilles' heel' by making them sensitive to unexpected drugs. For example, by analyzing data from 1,000 cell lines, the team could predict that when mutations of the genes ARID1A and RNF43 (involved in tumours of the colon, rectum, and stomach) co-occurred, became sensitive to VX-680, a inhibiting the Aurora kinase involved in cell proliferation.

The authors therefore provide a new way of thinking about cancer evolution: "Genetic alterations associated with the disease are not randomly picked based exclusively on their single effect, but combined and matched by evolution to maximize their synergy," concludes Ciriello.

To reach their findings, the team used the most comprehensive collection of molecular data from the Cancer Genome Atlas (TCGA) international consortium, which includes 6,456 human tumour samples derived from 23 types.

Such a map of oncogenic dependencies is a crucial first step to improve the design of personalized therapeutic approaches, and can serve as a reference for functional and pre-clinical studies.

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More information: Marco Mina et al. Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies, Cancer Cell (2017). DOI: 10.1016/j.ccell.2017.06.010
Journal information: Cancer Cell

Citation: Map of oncogenic dependencies for the design of personalized therapeutic approaches (2017, August 14) retrieved 26 February 2020 from
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