Telomere length prognostic in hepatocellular carcinoma

Telomere length prognostic in hepatocellular carcinoma

(HealthDay)—Telomere attrition occurs in tumor cells from patients with hepatocellular carcinoma (HCC), and shortened telomeres are independent prognosticators for HCC patients, according to a study published online Aug. 21 in the Journal of Pathology.

Li-Jie Ma, from Fudan University in Shanghai, and colleagues used telomere-specific fluorescence in situ hybridization and quantitative polymerase chain reaction to assess in HCC cell lines, , and nontumor cells within the tumor.

The researchers found that, compared with their normal counterparts, significant telomere attrition was found in tumor cells and cancer-associated fibroblasts (CAFs), but not in intratumor leukocytes or bile duct epithelial cells. On tissue microarrays of 257 surgically treated HCC patients, reduced intensity of telomere signals in tumor cells or CAFs were associated with larger tumor size and presence of vascular invasion (P < 0.05). There was a correlation for shortened telomeres in tumor cells or CAFs with reduced survival and increased recurrence, and they were independently prognostic for HCC patients (P < 0.05). The findings were validated in a cohort of 371 HCC patients from The Cancer Genome Atlas database. There was a correlation for telomerase reverse transcriptase promoter mutation with telomere shortening in HCC.

"Telomere variation in tumor cells and non- within the of HCC was a valuable prognostic biomarker for this fatal malignancy," the authors write.

Explore further

Boozing can age you right down to your cells

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Journal of Pathology

Copyright © 2017 HealthDay. All rights reserved.

Citation: Telomere length prognostic in hepatocellular carcinoma (2017, August 24) retrieved 15 December 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments