Etosis phenomenon discovered in human blood monocytes

September 1, 2017, Federation of American Societies for Experimental Biology
blood
Credit: Wikimedia Commons

A recent study published online in the Journal of Leukocyte Biology found the first clear demonstration of etosis in human blood monocytes, a type of immune cell. Etosis, a phenomenon previously presumed to be due to neutrophils (another type of immune cell) occurs when bloods cells cast a "DNA net" outside of the cell. This net, called the "extracellular trap," allows cells to trap and kill pathogens that would otherwise be too large to engulf. In addition to discovering the existence of etosis in human blood monocytes, the study also found that the extracellular traps could activate coagulation, which could have implications for how the coagulation process is triggered under inflammatory conditions.

"We believe that deciphering which can undergo etosis, and under which conditions, will provide a better understanding of inflammation," said Luc de Chaisemartin, PharmD, PhD, a researcher involved in the work from the Université Paris-Sud in Châtenay-Malabry, France. "We hope this research will ultimately lead to new diagnostic tools in a wide range of diseases, as well as therapeutic targets to prevent tissue damage in and thrombosis."

To make their discovery, Chaisemartin and colleagues isolated monocytes and neutrophils from the blood of healthy donors, stimulating them with both artificial and natural substances and comparing their DNA release using fluorescent probes and microscopy. The researchers found that monocytes reacted in nearly the same way as neutrophils, with the exception of some inhibitors having an effect on neutrophil DNA release and not monocyte DNA release.

"Inflammatory diseases have a huge clinical impact and underlying inflammation may have a role in a wide variety of apparently non-immunological diseases," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These new results should provide better clarity in how to target etosis and block or exploit this process for clinical benefit."

Explore further: Discovery of the monocytes that secrete a pro-inflammatory protein

Related Stories

Discovery of the monocytes that secrete a pro-inflammatory protein

August 10, 2017
Different populations of white blood cells secrete different levels of IL-1β, a pro-inflammatory protein that normally helps the body fight off infection and injury, but may also trigger autoimmune disease and inflammatory ...

Scientists identify missing link between smoking and inflammation

October 31, 2016
It's no secret that using tobacco is bad for you, but what has been a mystery until now is how tobacco causes increased inflammation throughout the body. Now, a team of researchers from the United States and Sweden have learned ...

Male and female mice respond differently to inflammation

November 2, 2015
New research published in the Journal of Leukocyte Biology shows that male and female mice respond differently to inflammation at the cellular level. Specifically, in male mice the spleen acts as a source of white blood cells, ...

Scientists discover the specific types of macrophages that affect Crohn's disease severity

February 28, 2014
For those coping with Crohn's disease, a new research report published in the Journal of Leukocyte Biology offers hope for the development of new and more effective drugs. In the report, scientists show for the first time, ...

Salt-inducible kinases may have therapeutic potential for autoimmune diseases

April 29, 2016
A new research report appearing in the May 2016 issue of the Journal of Leukocyte Biology, suggests that specific enzymes, called "salt-inducible kinases," may be able to help curb runaway inflammation associated with autoimmune ...

Recommended for you

New findings suggest allergic responses may protect against skin cancer

July 17, 2018
The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings.

The immune system: T cells are built for speed

July 17, 2018
Without T cells, we could not survive. They are a key component of the immune system and have highly sensitive receptors on their surface that can detect pathogens. The exact way that these receptors are distributed over ...

Broadly acting antibodies found in plasma of Ebola survivors

July 17, 2018
Recent Ebola virus disease (EVD) outbreaks, including the 2013-2016 epidemic that ravaged West Africa and the 2018 outbreak in the Democratic Republic of the Congo, highlight the need for licensed treatments for this often-deadly ...

How protein fragments could help to tackle the cause of hay fever

July 16, 2018
Imperial researchers are looking to protein fragments to help people build up resistance to grass pollen.

Team explores diabetes drug's ability to treat RSV infection

July 13, 2018
A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis—inflammation and obstruction of the lungs' small airways. A multi-disciplinary team of Vanderbilt investigators ...

Testing suggests TORC1 inhibitors can boost immune system in the elderly

July 12, 2018
A team of researchers affiliated with Novartis Institutes for Biomedical Research and Biometrics Matters Limited, has found via testing with volunteers that TORC1 inhibitors can boost the immune system in the elderly. In ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.