Monophasic HA filler noninferior to biphasic for nasolabial folds

September 20, 2017

(HealthDay)—Monophasic hyaluronic acid (HA) filler is safe and effective for correction of nasolabial folds (NLFs), according to a study published online Sept. 14 in the Journal of Cosmetic Dermatology.

Hyun Jung Kwon, M.D., from the Chung-Ang University College of Medicine in Seoul, South Korea, and colleagues compared the rheological properties, efficacy, and safety of a monophasic HA filler and a well-studied biphasic HA filler in 72 Korean subjects with moderate-to-severe NLFs. The Wrinkle Severity Rating Scale (WSRS) was used for assessments at two, 10, 18, 26, and 52 weeks.

The researchers found that at week 26, the mean WSRS score was 2.26 for the monophasic HA side and 2.24 for the biphasic HA side. Both treatments were well tolerated. Adverse reactions were mild and transient. Compared to the biphasic HA filler, the monophasic HA filler had lower elasticity and higher viscosity.

"Despite a number of different rheological properties, monophasic HA is noninferior to biphasic HA in the treatment of moderate-to-severe NLFs for 52 weeks," the authors write.

Explore further: Monophasic HA filler plus lidocaine corrects nasolabial folds

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Monophasic HA filler plus lidocaine corrects nasolabial folds

February 9, 2017
(HealthDay)—The monophasic hyaluronic acid (HA) filler with lidocaine, Dermalax implant plus (PLUS), is not inferior to the biphasic HA Restylane Sub-Q (Sub-Q) for correcting nasolabial folds (NLFs), according to a study ...

Polycaprolactone efficient for nasolabial fold treatment

January 15, 2015
(HealthDay)—For patients with nasolabial folds (NLFs), treatment with a novel biostimulatory polycaprolactone (PCL)-based dermal filler is associated with improved long-lasting efficacy compared with nonanimal stabilized ...

Hyaluronic acid filler deemed safe, effective for neck lines

July 26, 2017
(HealthDay)—Hyaluronic acid (HA) filler injection seems to be efficacious and safe for the treatment of horizontal neck lines, according to research published online July 20 in the Journal of Cosmetic Dermatology.

Hyaluronic acid, autologous fat augment nasolabial folds

March 20, 2017
(HealthDay)—Hyaluronic acid (HA) and autologous fat are both beneficial for augmentation of nasolabial folds (NLFs), according to a study published online March 14 in the Journal of Cosmetic Dermatology.

Platelet-rich plasma injection reduces facial wrinkles

August 8, 2016
(HealthDay)—Platelet-rich plasma (PRP) intradermal injection can reduce wrinkles, especially wrinkles of the nasolabial folds (NLFs), according to a study published online July 29 in the Journal of Cosmetic Dermatology.

Patient satisfaction high with filler for midface volumization

October 24, 2016
(HealthDay)—Low-volume hyaluronic acid filler is effective for correction of age-related midface volume loss, according to a study published online Oct. 19 in JAMA Facial Plastic Surgery.

Recommended for you

Scientists identify potential drug target in blood-feeding hookworms

March 22, 2018
In hookworms that infect and feed on the blood of mice, scientists have discovered a key step in blood digestion that can be targeted to disrupt the parasite's development and survival. These findings, published in PLOS Pathogens ...

Global burden of low back pain—a consequence of negligence and misinformation

March 21, 2018
A series of groundbreaking papers from Australian and international researchers in The Lancet, published today (22/3) warns that low back pain is a major health burden globally - across developed and developing nations - ...

Microscopic 'shuttles' transport enzyme from cells to trigger onset of kidney disease

March 21, 2018
A new study involving the University of Sheffield has identified a key culprit in the onset of kidney disease in a major marker for kidney disease development.

Metabolite therapy proves effective in treating C. difficile in mice

March 20, 2018
A team of UCLA researchers found that a metabolite therapy was effective in mice for treating a serious infection of the colon known as Clostridium difficile infection, or C. difficile.

Study of COPD patients has created a 'looking glass' into genome of pathogen

March 19, 2018
Decades of work on chronic obstructive pulmonary disease (COPD) at the University at Buffalo and the Veterans Affairs Western New York Healthcare System have yielded extraordinary information about the pathogen that does ...

Sick air travelers mostly likely to infect next row: study

March 19, 2018
People who fly on airplanes while contagious can indeed get other people sick, but the risk is mainly to those seated next to them or in the adjacent row, US researchers said Monday.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.