Best poster at ESMO 2017 shows positive trials twice as likely to be reported in lay press

September 12, 2017

Randomised controlled trials with positive results are twice as likely to be reported by the lay press as those with negative trials, according to results from the Best Poster in Public Health and Health Economics at the ESMO 2017 Congress in Madrid. Trials on immunotherapy and targeted therapy were more commonly reported than those on chemotherapy.

The Best Poster in Public Health and Health Economics was chosen by judge Dr José M. Martin-Moreno, Professor of Medicine and Public Health, University of Valencia, Spain, out of 47 posters on the topic presented at ESMO 2017.

Conducted by researchers in Canada, Israel, Spain, Switzerland, and Slovenia, the study explored the role of the lay media in disseminating the results of randomised controlled trials in common cancers. It also looked at factors that determined whether a trial was reported in the lay press before it was presented at a scientific conference or published in a scientific journal (referred to as 'early reporting' by the researchers).

The analysis included 180 phase III randomised controlled trials in breast, colorectal, lung and that were completed between January 2005 and October 2016. More than half (52%) of trials were reported in the lay media and more than one-quarter (27%) were reported before a scientific presentation or publication.

The researchers found that early reporting of trial results by the lay press was twice as likely if the trial was positive compared to negative, nearly five times as likely if the trial was about targeted therapy compared to chemotherapy, nearly eight times as likely if the trial concerned immunotherapy instead of chemotherapy, and three times as likely if the trial was in prostate rather than breast .

Lead author Dr Domen Ribnikar, a clinical research fellow at the Princess Margaret Cancer Centre in Toronto, Canada, said: "We found that the lay press are more likely to write stories about cancer before a scientific presentation or publication if they have positive results, are about immunotherapy or targeted therapy, or cover prostate cancer. It seems likely that readers of lay media are not getting an accurate view of oncology drug development."

Martin-Moreno said: "The lay press is a key source of information about cancer for patients and the public which makes this an important topic. This poster puts its finger on an important problem; it would be preferable if the media did report that have been previously peer reviewed by journals or by scientific committees at meetings."

"The authors were a young group of researchers from different countries who have shed some light on an interesting subject that has not been extensively studied," he added.

Explore further: Alectinib: ALEX and ALUR trials show CNS benefit in NSCLC

More information: Abstract 1447P 'Reporting of results of randomized trials in common cancers in the lay media' was presented by Domen Ribnikar during a Poster Display session on CNS Tumours on Sunday, 10 September, 13:15 to 14:15 (CEST) in Hall 8.

Related Stories

Alectinib: ALEX and ALUR trials show CNS benefit in NSCLC

September 6, 2017
Data from two separate phase 3 studies to be presented at the ESMO 2017 Congress in Madrid, show alectinib's particular central nervous system (CNS) activity in patients with advanced non-small cell lung cancer involving ...

Lung cancer clinical trial elig criteria and requirements increased in number and complexity

August 10, 2017
Eligibility criteria continue to increase in number and complexity for lung cancer clinical trials.

Patients with high risk prostate cancer may benefit 'equally' from two new treatments

September 8, 2017
Patients with high risk prostate cancer starting long-term hormone therapy may benefit from two new treatments, according to late-breaking results from the STAMPEDE trial presented at the ESMO 2017 Congress in Madrid. (1)

Cancer patients struggle with key aspects of clinical trial methodology

September 10, 2017
Clinical trials are fundamental to the development of new treatments for cancer, yet the annual accrual to cancer clinical trials worldwide is low, estimated at three to five percent. A nationwide study in Ireland, the preliminary ...

Clinical trials often unregistered, unpublished

September 11, 2017
An analysis of more than 100 clinical trials found that they were often unregistered, unpublished and had discrepancies in the reporting of primary outcomes, according to a study published by JAMA. The study is being released ...

Study confirms chemoradiation is best treatment for locally advanced cervical cancer

September 11, 2017
A 14-year randomised trial in more than 600 patients has concluded that chemoradiation should remain the standard treatment for patients with locally advanced cervical cancer. The findings are reported today at the ESMO 2017 ...

Recommended for you

Lung cancer triggers pulmonary hypertension

November 17, 2017
Shortness of breath and respiratory distress often increase the suffering of advanced-stage lung cancer patients. These symptoms can be triggered by pulmonary hypertension, as scientists at the Max Planck Institute for Heart ...

Researchers discover an Achilles heel in a lethal leukemia

November 16, 2017
Researchers have discovered how a linkage between two proteins in acute myeloid leukemia enables cancer cells to resist chemotherapy and showed that disrupting the linkage could render the cells vulnerable to treatment. St. ...

Computer program finds new uses for old drugs

November 16, 2017
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, ...

Pharmacoscopy improves therapy for relapsed blood cancer in a first clinical trial

November 16, 2017
Researchers at CeMM and the Medical University of Vienna presented a preliminary report in The Lancet Hematology on the clinical impact of an integrated ex vivo approach called pharmacoscopy. The procedures measure single-cell ...

Wider sampling of tumor tissues may guide drug choice, improve outcomes

November 15, 2017
A new study focused on describing genetic variations within a primary tumor, differences between the primary and a metastatic branch of that tumor, and additional diversity found in tumor DNA in the blood stream could help ...

A new strategy for prevention of liver cancer development

November 14, 2017
Primary liver cancer is now the second leading cause of cancer-related death worldwide, and its incidences and mortality are increasing rapidly in the United Stated. In late stages of the malignancy, there are no effective ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.