Researchers help develop new antifungal drug

October 6, 2017, University of Liverpool
Aspergillosis. Credit: Wikipedia

University of Liverpool researchers, working with F2G Limited (Eccles, Manchester), have developed a new antifungal drug to help in the treatment of life threatening invasive fungal infections such as invasive aspergillosis.

Invasive fungal infections are common and often lethal. Despite optimal medical care mortality is 20-30% at six weeks and dramatically rises to 80-100% for resistant .

These infections occur most commonly in the context of leukemia and and often in young patients with otherwise curable disease.

Orotomides

The researchers, led by Professor William Hope from the University's Antimicrobial Pharmacodynamics and Therapeutics (APT) Group, have characterised the biochemical and physiologic effects (pharmacodynamics) of F901318, which is the lead compound of the new class of drugs termed the 'orotomides'.

The 'orotomides', discovered by F2G Limited, have a novel mechanism of action which is the specific biochemical interaction through which a drug substance produces its pharmacological effect.

This is the first new class of to be discovered in the last three decades.

The study, which was supported by a research grant by F2G, has been published in mBio.

Clinical studies

APT's work provides the underpinning evidence for efficacy and dosage justification for the very first patients receiving the new drug. Such information is required by regulatory agencies such as the European Medicines Agency and the Food and Drug Administration before can proceed.

Professor Hope, said: "Antifungal resistance represents a major global clinical challenge. This study provides the necessary information to enable F901318 to be developed for clinical use."

Explore further: New antifungal as effective as existing drugs with fewer adverse events

More information: William W. Hope et al, Pharmacodynamics of the Orotomides against Aspergillus fumigatus : New Opportunities for Treatment of Multidrug-Resistant Fungal Disease, mBio (2017). DOI: 10.1128/mBio.01157-17

Related Stories

New antifungal as effective as existing drugs with fewer adverse events

September 7, 2014
A newly developed antifungal, isavuconazole, is as effective as an existing drug, voriconazole, against invasive mold disease in cancer patients with less adverse effects, according to phase 3 clinical data presented at the ...

FDA approves cresemba for serious fungal infections

March 9, 2015
(HealthDay)—Cresemba (isavuconazonium sulfate) has been approved by the U.S. Food and Drug Administration to treat invasive aspergillosis and invasive mucormycosis, the agency said Friday in a news release.

Fungal disease spreads through UK hospitals – here's what you need to know about _Candida auris_

August 18, 2017
At least 20 NHS Trust hospitals have been hit by a drug-resistant fungus, Candida auris. So far, 200 people have been contaminated or infected with the fungus, which can cause potentially deadly complications.

Novel algorithm predicts drug combinations to treat drug resistant fungal infections

July 14, 2016
Scientists have created an algorithm that can identify drug combinations to treat fungal infections that have become resistant to current drug treatments. This new study, published in PLOS Computational Biology, represents ...

Neutralization of pathogenic fungi with small-molecule immunotherapeutics

September 20, 2017
Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics ...

UK burden of fungal asthma greatly exceeds prior estimates, new study warns

November 16, 2016
Experts are warning of a significant increase in the number of people in the UK who are living with invasive and serious fungal diseases that affect the lungs, bloodstream and brain and can sometimes lead to death.

Recommended for you

Polio: Environmental monitoring will be key as world reaches global eradication

October 15, 2018
Robust environmental monitoring should be used as the world approaches global eradication of polio, say University of Michigan researchers who recently studied the epidemiology of the 2013 silent polio outbreak in Rahat, ...

Study traces hospital-acquired bloodstream infections to patients' own bodies

October 15, 2018
The most common source of a bloodstream infection acquired during a hospital stay is not a nurse's or doctor's dirty hands, or another patient's sneeze or visitor's cough, but the patient's own gut, Stanford University School ...

Researchers make essential imaging tests safer for people at risk of acute kidney injury

October 15, 2018
Every year, millions of people undergo medical tests and procedures, such as coronary angiography, which use intravascular contrast dyes. "For the majority of patients, these are safe and necessary procedures. However, about ...

Medical marijuana might help MS patients, but uncertainty remains

October 13, 2018
Medical products derived from marijuana might have a mild benefit in treating symptoms of multiple sclerosis, based on reports from patients.

Do not give decongestants to young children for common cold symptoms, say experts

October 11, 2018
Decongestants should not be given to children under 6—and given with caution in children under 12—as there is no evidence that they alleviate symptoms such as a blocked or runny nose, and their safety is unclear, say ...

New techniques can detect Lyme disease weeks before current tests

October 11, 2018
Researchers have developed techniques to detect Lyme disease bacteria weeks sooner than current tests, allowing patients to start treatment earlier.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.