Immune response to ovarian cancer may predict survival, study finds

October 12, 2017, Mayo Clinic
Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left - diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen at the top of image. Credit: Nephron /Wikipedia. CC BY-SA 3.0

A group of international cancer researchers led by investigators from Mayo Clinic and University of New South Wales Sydney has found that the level of a type of white blood cell, called tumor-infiltrating lymphocytes, present in the tumors of patients with high-grade ovarian cancer may predict a patient's survival. Results of the study by the Ovarian Tumor Tissue Analysis Consortium were published today in JAMA Oncology.

"We know that a type of tumor-infiltrating lymphocyte called cytotoxic CD8 are present in the tumors of patients with high-grade ovarian cancer," says Matthew Block, M.D., Ph.D., a Mayo Clinic oncologist who co-led the research team with Ellen Goode, Ph.D., of the Mayo Clinic Cancer Center Genetic Epidemiology and Risk Assessment Program. "However, little was known about the role in fighting high-grade ovarian cancer, compared to other clinical factors."

To help answer this question, researchers studied more than 5,500 patients from nine different countries, including 3,196 with high-grade ovarian cancer. Researchers found that patients with high-grade ovarian cancer showed the most infiltration with tumor-infiltrating lymphocytes, which were associated with longer overall survival.

"This study shows the higher the level of cytotoxic CD8 tumor-infiltrating lymphocytes in a tumor, the better the survival for patients with high-grade ovarian cancer," says Dr. Block. "Developing a better understanding of factors that increase cytotoxic CD8 tumor-infiltrating will be the key to developing treatments to achieve better outcomes in treating with high-grade ovarian .

"This is by far the largest study of this type and would not have been possible without scientists from North and South America, Europe and Australia all working together," says Susan Ramus, Ph.D., University of New South Wales Sydney.

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