Kidney damage seen in most patients with long-lasting T1D

October 30, 2017

(HealthDay)—Most patients with type 1 diabetes (T1D) of long duration have some degree of kidney disease, according to a study published online Oct. 4 in Diabetes Care.

Tina Costacou, Ph.D., and Trevor J. Orchard, M.D., from the University of Pittsburgh examined the 50-year cumulative complication risk in 932 participants from a childhood-onset T1D cohort diagnosed during 1950 to 1980. Overall, 144 participants died before baseline (1986 to 1988), 130 were followed with periodic surveys, and 658 were followed with biennial surveys.

The researchers found that end-stage renal (ESRD) affected 60 percent of the cohort by 50 years of T1D duration, while macroalbuminuria and microalbuminuria affected 72 and 88 percent, respectively. In recent cohorts there was little evidence for declines in cumulative incidence, except for ESRD, which had a 45 percent decrease by 40 years of T1D duration, while microalbuminuria increased 3 percent and macroalbuminuria did not change. The lowest risk was seen for onset before age 6 years, and there was usually no difference in incidence by sex.

"Some degree of in T1D is virtually universal at long durations and not declining, which has major implications for health care and research strategies," the authors write.

Explore further: Cumulative incidence of ESRD low in patients with type 1 DM

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Cumulative incidence of ESRD low in patients with type 1 DM

November 8, 2016
(HealthDay)—Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published ...

Metabolites linked to renal decline, time to ESRD in T1DM

January 19, 2017
(HealthDay)—Serum levels of seven modified metabolites are associated with renal function decline and time to end-stage renal disease (ESRD) among patients with type 1 diabetes (T1D), according to a study published online ...

Liraglutide tied to reduced progression of diabetic kidney disease

September 4, 2017
(HealthDay)—For patients with type 2 diabetes and high cardiovascular risk receiving usual care, the addition of liraglutide is associated with lower rates of development and progression of diabetic kidney disease, according ...

Valsartan cuts microalbuminuria in impaired glucose tolerance

February 9, 2017
(HealthDay)—For patients with impaired glucose tolerance (IGT), valsartan is associated with reduced incidence of microalbuminuria, according to a study published online Jan. 17 in Diabetes, Obesity and Metabolism.

Nonalcoholic fatty liver disease linked to CKD in T1DM

April 9, 2014
(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published online April 2 in ...

Recommended for you

Lentils significantly reduce blood glucose levels, study reveals

June 13, 2018
Replacing potatoes or rice with pulses can lower your blood glucose levels by more than 20 per cent, according to a first-ever University of Guelph study.

Is there a link between diabetes and Parkinson's disease?

June 13, 2018
People with type 2 diabetes may have an increased risk of having a diagnosis of Parkinson's disease later in life, according to a large study published in the June 13, 2018, online issue of Neurology, the medical journal ...

Double-checking diabetes medications may reduce re-hospitalizations

June 11, 2018
Clinicians may take upwards of 15 minutes to double-check a patient's medication list in an electronic health record system, but according to a new study, this reconciliation process may be well worth the time for diabetes ...

How a gene linked to obesity could provide new insights into diabetes

June 8, 2018
A gene previously linked with obesity has been found to affect how the body processes insulin, with potential implications for some forms of diabetes.

New hope from the 'seven year switch' in type 1 diabetes

June 8, 2018
New research has shown that the rapid decline in insulin production that causes Type 1 diabetes continues to fall over seven years and then stabilises.

Diabetes results from a breakdown of epigenetic control

June 5, 2018
Diabetes affects more than 400 million individuals worldwide. In what is becoming a paradigm shift, researchers have begun to find that the disease may result in part through pancreatic beta cells losing their functional ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.