Cinnamon shows potential as tool in fight against obesity

November 27, 2017

(HealthDay)—The compound cinnamaldehyde (CA), found in cinnamon, activates fat cells to start burning energy in both mice and humans, according to a study published in the December issue of Metabolism.

Juan Jiang, from the University of Michigan in Ann Arbor, and colleagues used a mouse model assessing the cell-autonomous response of primary adipocytes to CA treatment. Additionally, human adipose stem were differentiated and treated with CA to assess whether the CA-mediated signaling was present in humans, too.

The researchers found that in murine primary adipocytes, CA significantly activated PKA signaling, increased expression levels of thermogenic genes, and induced phosphorylation of hormone-sensitive lipase and protein perilipin 1. The CA-induced thermogenic response was inhibited with inhibition of PKA or p38 MAPK enzymatic activity. Chronic CA treatment was found to regulate metabolic reprogramming, which was partially diminished in FGF21KO adipocytes. Both acute and chronic effects of CA were seen in human adipose stem cells, which were isolated from donors of different ethnicities, ages, and a variety of body mass indexes.

"Given the wide usage of cinnamon in the food industry, the notion that this popular food additive, instead of a drug, may activate thermogenesis, could ultimately lead to therapeutic strategies against obesity that are much better adhered to by participants," the authors write.

Explore further: Cinnamon turns up the heat on fat cells

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Cinnamon turns up the heat on fat cells

November 21, 2017
New research from the University of Michigan Life Sciences Institute has determined how a common holiday spice—cinnamon—might be enlisted in the fight against obesity.

Improving control of age-related obesity

May 4, 2017
The function and distribution of adipose tissue in the body change during the course of life. Beige fat cells, a special type of adipocytes, have the capability to use energy reserves - fatty deposits - by generating heat ...

Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

March 11, 2016
Brown adipose tissue (BAT), a major site for mammalian non-shivering thermogenesis, could be a target for prevention and treatment of human obesity. Transient receptor potential vanilloid 2 (TRPV2), a Ca2+-permeable cation ...

Metformin combats adipose tissue expansion via AMPK

May 24, 2016
(HealthDay)—AMPK activation by metformin is associated with inhibition of interstitial fibrosis and suppression of transforming growth factor β-1 (TGF-β1), according to a study published online May 13 in Diabetes.

Fat cells may inactivate chemotherapeutic drug

November 8, 2017
Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment outcomes.

Making metabolically active brown fat from white fat-derived stem cells

March 3, 2017
Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells (ASCs). The ...

Recommended for you

Wide waist with 'normal weight' bigger risk than obesity: study

April 20, 2018
People of "normal" weight who sport a wide waist are more at risk of heart problems than obese people, said researchers Friday, urging a rethink of healthy weight guidelines.

Lack of sleep leads to obesity in children and adolescents

April 16, 2018
Children who get less than the recommended amount of sleep for their age are at a higher risk of developing obesity.

Getting kids to a good weight by 13 may help avoid diabetes

April 4, 2018
There may be a critical window for overweight kids to get to a healthy level. Those who shed their extra pounds by age 13 had the same risk of developing diabetes in adulthood as others who had never weighed too much, a large ...

Obesity is shifting cancer to young adults

March 26, 2018
A Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults. The meta-analysis describes ...

Obesity rates keep rising for U.S. adults

March 23, 2018
Obesity rates have continued to climb significantly among American adults, but the same hasn't held true for children, a new government report finds.

Obesity trigger identified within the human gut

March 22, 2018
The key chemical for happiness and sadness, serotonin, is also a force in our body's weight gain and calorie control, and scientists say more research could reduce obesity rates.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.