5-fluorouracil promising for vaginal intraepithelial neoplasia

November 21, 2017

(HealthDay)—5-fluorouracil is associated with a 74 percent success rate as the initial treatment modality for high-grade intraepithelial vaginal dysplasia, according to a study published online Nov. 7 in Obstetrics & Gynecology.

Stephen Fiascone, M.D., from Brigham and Women's Hospital in Boston, and colleagues retrospectively reviewed the cases of women referred to a single center for management of high-grade vaginal intraepithelial neoplasia between April 1994 and May 2016 to assess the success rates of 5-fluorouracil, excision, and laser ablation as the initial and secondary management strategies.

The researchers found that 47 patients were treated initially with 5-fluorouracil, 35 were treated with excision, and 22 were treated with laser . The groups were similar demographically. There was no recurrence in 35 women treated with 5-fluorouracil (74 percent), 20 treated with excision (57 percent), or nine treated with (41 percent). Eight of the 13 patients treated with 5-fluorouracil for recurrence did not experience a second . Side effects were reported in nine of 58 (16 percent) ever treated with 5-fluorouracil, most commonly irritation and dyspareunia.

"The optimal treatment strategy for women with recurrent or persistent vaginal intraepithelial neoplasia is unclear from the current literature, and the data presented here show that topical 5-fluorouracil may have an important role in this context, especially given the morbidity associated with repeated vaginal surgeries," the authors write.

Explore further: Abnormal pap posthysterectomy for 30 percent of HIV+ women

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Abnormal pap posthysterectomy for 30 percent of HIV+ women

June 14, 2016
(HealthDay)—About one-in-three HIV-infected women with no prehysterectomy history of abnormal Pap results have abnormal vaginal Pap results after hysterectomy, according to a study published in the July issue of Obstetrics ...

Laser removal may be advantageous for treating precancerous skin lesions

November 21, 2011
Carbon dioxide laser ablation (removal) may have a role as an alternative treatment for a common precancerous skin lesion known as lentigo maligna when surgery or radiation therapy is not feasible, according to a report in ...

FDA approves new pancreatic cancer drug

October 22, 2015
(HealthDay)—The U.S. Food and Drug Administration has approved a new drug called Onivyde as part of a treatment regimen for advanced pancreatic cancer.

Staged surgical excision superior for treatment of lentigo maligna

December 9, 2015
(HealthDay)—For patients with lentigo maligna, staged surgical excision is associated with a low rate of recurrence, according to research published online Nov. 30 in the British Journal of Dermatology.

Goal in stage Ia1 cervical cancer is complete excision

December 23, 2014
(HealthDay)—Clear excision margins are important in the management of stage Ia1 squamous cervical cancer, according to research published in the December issue of the American Journal of Obstetrics & Gynecology.

Endometrial ablation doesn't increase cancer risk

August 14, 2017
(HealthDay)—For women in Finland, endometrial ablation is not associated with increased risk of endometrial or breast cancer, according to a study published in the September issue of Obstetrics & Gynecology.

Recommended for you

Discovery promises improved diagnosis and understanding of endometriosis

March 19, 2018
Feinstein Institute for Medical Research scientists announced an experimental, rapid and non-invasive way to diagnose endometriosis, which may lead to earlier and more effective treatments for this disorder that affects approximately ...

Vaginal estrogen tablets, moisturizers and placebo gel all can improve vaginal discomfort

March 19, 2018
A clinical trial comparing two treatments for postmenopausal vaginal discomfort - low-dose vaginal estrogen and a vaginal moisturizer - to placebo treatments found that both produced symptom improvements similar to those ...

Frozen embryos more successful for conceiving during IVF

March 19, 2018
A new study carried out by a research team at The University of Western Australia and Fertility Specialists of Western Australia has found that women undergoing IVF who have had embryos fail to implant have more success using ...

Alomst 70 percent of 103 genes linked to prenatal death affect the placenta

March 14, 2018
The role of the placenta in healthy fetal development is being seriously under-appreciated according to a new paper published today (14th March). The study was part of the Wellcome Trust-funded "Deciphering the Mechanisms ...

New research shows why babies need to move in the womb

March 12, 2018
Scientists have just discovered why babies need to move in the womb to develop strong bones and joints. It turns out there are some key molecular interactions that are stimulated by movement and which guide the cells and ...

Labour–inducing drugs put to the test

February 27, 2018
Researchers comparing the use of two drugs for pregnant women who do not go into labour shortly after their waters break have found both are reasonable options.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.