Meningococcal vaccine could protect against 91 percent of targeted bacterial strains

November 22, 2017, American Society for Microbiology

Up to 91 percent of bacterial strains causing a common type of invasive serogroup B meningococcal disease in children and young adults are likely to be covered by a four-component vaccine called MenB-4C (Bexsero), according to laboratory studies conducted by investigators at the federal Centers for Disease Control and Prevention (CDC) and at GlaxoSmithKline, manufacturer of the vaccine. The work was published this week in mSphere, an open access journal from the American Society for Microbiology.

Researchers used a laboratory test called the Meningococcal Antigen Typing System (MATS) to study the coverage potential of the MenB-4C , which was approved by the Food and Drug Administration in January 2015 for use in individuals ages 10-25 years. The vaccine contains 4 antigens to prevent invasive meningococcal disease caused by the serogroup B form of the bacteria Neisseria meningitidis: factor H binding protein (fHBP), Neisserial heparin binding protein (NHBA), Neisserial adhesin A (NadA) and PorA-containing outer membrane vesicles. These antigens are found on the bacteria, and vaccination with them induces an immune response in the recipients that helps protect them from infection by the bacteria that carry the antigens. In the United States in 2015, serogroup B of the bacteria caused approximately 40 percent of in all age groups, including adolescents, and over 60 percent of cases in infants aged less than one year.

Researchers tested 442 N. meningitidis serogroup B samples collected by CDC from 2000 to 2008. The MATS test predicted that 91 percent of these causing meningococcal disease in the United States would be covered by the MenB-4C vaccine, with an estimated coverage ranging from 88 percent to 97 percent each year.

More than half of the covered strains could be targeted by two or more antigens in the vaccine, the investigators found. NHBA covered 83 percent of the strains, fHBP covered 53 percent of the strains, PorA covered 5.9 percent of the strains and NadA covered 2.5 percent of the strains.

"We are very pleased to see that it looks like the vaccine has the potential to cover most of the strains of meningococcal Group B bacteria currently circulating in the U.S.," said lead study author Gowrisankar Rajam, Ph.D., health scientist at CDC. "However, we need to continue our analysis to assess the coverage of currently circulating strains in the U.S. We are confident the MATS technique will be very useful at detecting any changes in bacterial expression of these antigens."

Neisseria meningitidis is a leading cause of bacterial meningitis in children and , resulting in significant morbidity and mortality worldwide. Meningococcal disease is a life-threatening illness that can infect the bloodstream and the lining that surrounds the brain and spinal cord. The bacteria can be transmitted from person to person through close or prolonged contact with respiratory or throat secretions, such as by coughing, kissing or living in close quarters.

Another vaccine against serogroup B meningococcal disease, called Trumenba, was approved by the FDA in October 2014. Previous vaccines were available to protect against meningococcal caused by N. meningitidis serogroups A, C, Y and W but not against serogroup B.

Explore further: MenB vaccine recommended for 16- to 23-year-olds

Related Stories

MenB vaccine recommended for 16- to 23-year-olds

October 26, 2015
(HealthDay)—Serogroup B meningococcal (MenB) vaccination is recommended for adolescents and young adults aged 16 to 23 years to provide short-term protection from most strains of serogroup B meningococcal disease, according ...

Study reveals potential improvements for effectiveness of meningococcal vaccines

September 9, 2016
A study conducted by UCSF Benioff Children's Hospital Oakland Research Institute (CHORI) scientists shows greatly improved protective antibody responses to a new mutant vaccine antigen for prevention of disease caused by ...

Investigational MenB vaccine can protect individuals in outbreak

April 30, 2015
(HealthDay)—An investigational serogroup B meningococcal (MenB) vaccine seems to have protected vaccinated individuals from the disease during an outbreak, according to a study published online April 27 in Pediatrics.

FDA approves second vaccine against meningitis strain

January 23, 2015
Federal health regulators have approved a second vaccine to prevent a strain of bacteria that can cause deadly cases of meningitis.

Varied immunity by age five in children vaccinated with serogroup B meningococcus as babies

March 23, 2015
Young children who received the 4CMenB vaccine as infants to protect against serogroup B meningococcal disease had waning immunity by age 5, even after receiving a booster at age 3 ½, according to new research in CMAJ (Canadian ...

Administration of meningococcal vaccine with other routine infant vaccines appears effective

February 7, 2012
Administration of routine infant immunizations with a vaccine for serogroup B Neisseria meningitidis, a bacterium that is a cause of serious disease such as sepsis and meningitis, was effective against meningococcal strains ...

Recommended for you

Deadly Rift Valley fever: New insight, and hope for the future

July 19, 2018
Health control measures alone could be ineffective in the long term fight against the deadly Rift Valley fever which affects both humans and animals, a new study in the journal PNAS reports.

New guidelines to diagnose, manage rare endocrine disorders

July 19, 2018
International guidelines have been published for the first time to help doctors around the globe diagnose and manage patients with a very rare set of endocrine diseases known as pseudohypoparathyroidism and its related disorders, ...

Overuse of antibiotics not what the doctor ordered

July 19, 2018
With increased use of antibiotics worldwide linked to growing antibiotic resistance, a world-first study co-authored by a QUT researcher has highlighted the growing impact of non-prescription supply of antibiotics in community ...

Alcohol-related cirrhosis deaths skyrocket in young adults

July 18, 2018
Deaths from cirrhosis rose in all but one state between 1999-2016, with increases seen most often among young adults, a new study shows.

Hidden blood in feces may signal deadly conditions

July 17, 2018
(HealthDay)—Even if it's not visible to the naked eye, blood in the stool can be serious—a sign of a potentially fatal disease other than colon cancer, new research suggests.

Childhood abuse linked to greater risk of endometriosis, study finds

July 17, 2018
Endometriosis, a painful condition that affects one in 10 reproductive-age women in the U.S., has been linked to childhood physical and sexual abuse, according to findings published today in the journal Human Reproduction.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.