Cancer therapies may trigger aging phenotypes in survivors

December 19, 2017

(HealthDay)—Cancer therapies have direct effects on telomere length, epigenetic modifications, and microRNA, which can mimic phenotypes of aging, according to a review published online Dec. 18 in ESMO Open.

Noting that have an earlier onset and increased incidence of chronic comorbidities than the general population, Margaret C. Cupit-Link, from the Mayo Clinic in Rochester, Minn., and colleagues conducted a systematic review to examine the cellular biology of aging and/or mechanisms of cancer therapies similar to aging mechanisms.

The researchers identified multiple biological processes of aging at the cellular level and correlations with cancer therapies and clinical effects. Various chemotherapies and radiation had direct effects on , senescent cells, , and microRNA. Cancer survivors exhibited long-term comorbidities that mimic the phenotypes of aging and may result from the interaction between therapeutic exposures and the underlying biology of aging.

"Long-term follow-up of cancer survivors and research on prevention strategies should be pursued to increase the length and quality of life among the growing population of cancer survivors," the authors write.

Explore further: Risk for aging-related diseases elevated among thyroid cancer survivors

More information: Abstract/Full Text

Related Stories

Risk for aging-related diseases elevated among thyroid cancer survivors

November 22, 2017
Risk for aging-related diseases such as heart disease and diabetes was significantly higher among thyroid cancer survivors in Utah than it was among age-matched, cancer-free individuals, with those diagnosed before age 40 ...

In cancer and aging, interconnected roles for apoptosis and cellular senescence

July 13, 2016
A common feature of cancer and aging is cells' reduced ability to respond to stress-induced damage to DNA or cellular structures. Specifically, changes occur in the protective processes of apoptosis and cellular senescence, ...

Study links body fat, weight loss, and chromosome length in breast cancer patients

December 8, 2015
It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn't been clear. Now, Yale Cancer Center researchers have found an explanation in the tiny protective ...

Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors

March 28, 2014
Adjuvant chemotherapy for breast cancer is "gerontogenic", accelerating the pace of physiologic aging, according to a new study published March 28 in the Journal of the National Cancer Institute.

Increasing prevalence of obesity in cancer survivors

August 1, 2016
(HealthDay)—From 1997 to 2014 the estimated rate of annual increase in obesity prevalence was higher for adults with a history of cancer, according to a study published online July 25 in the Journal of Clinical Oncology.

Recommended for you

Resetting the epigenetic balance for cancer therapy

May 22, 2018
Though mutations in a gene called MLL3 are common across many types of cancers, their relationship to the development of the disease has been unclear. Now, a Northwestern Medicine study has identified an epigenetic imbalance ...

Compound in citrus oil could reduce dry mouth in head, neck cancer patients

May 21, 2018
A compound found in citrus oils could help alleviate dry mouth caused by radiation therapy in head and neck cancer patients, according to a new study by researchers at the Stanford University School of Medicine.

Ice cream funds research showing new strategy against thyroid cancer

May 21, 2018
Anaplastic thyroid cancer is almost uniformly fatal, with an average lifespan of about 5 months after diagnosis. And standard treatment for the condition includes 7 weeks of radiation, often along with chemotherapy.

Bladder cancer model could pave the way for better drug efficacy studies

May 21, 2018
Understanding that not all bladder cancers are the same, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have created a tool that may help them to uncover why only a fraction of patients ...

Breath test breakthrough for early diagnosis of oesophageal and gastric cancer

May 18, 2018
A breath test can successfully detect oesophageal and gastric cancer and could be used as a first-line test for patients, say researchers.

MR spectroscopy imaging reveals effects of targeted treatment of mutant IDH1 gliomas

May 18, 2018
Using a novel imaging method, a Massachusetts General Hospital (MGH) research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas. In their report ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.