Diabetes, but not diabetes drug, linked to poor pregnancy outcomes

New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes—such as major birth defects and pregnancy loss—than the general population, but their increased risk is not due to metformin but diabetes.

The findings come from a British Journal of Clinical Pharmacology study including 471 women in the metformin group and 479 in the reference group.

"Our findings provide the first reassuring evidence that metformin might offer a cheaper and simpler alternative to insulin for the management of pregestational diabetes in pregnancy when effective," said lead author Dr. Alice Panchaud, of the Harvard T.H. Chan School of Public Health, Lausanne University Hospital, and Geneva University.


Explore further

Diabetes drug metformin inhibits multidrug-resistant breast cancer

More information: Alice Panchaud et al, Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services, British Journal of Clinical Pharmacology (2017). DOI: 10.1111/bcp.13481
Provided by Wiley
Citation: Diabetes, but not diabetes drug, linked to poor pregnancy outcomes (2017, December 20) retrieved 18 June 2019 from https://medicalxpress.com/news/2017-12-diabetes-drug-linked-poor-pregnancy.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
10 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more