Scientists open the door to the development of better analgesics for treating joint pain

December 19, 2017, University of Granada
UGR researchers that carried out the study. From left to right: Gloria Perazzoli, Ángeles Montilla García, Enrique J Cobos del Moral, José Manuel Entrena Fernández and Miguel Ángel Tejada Giráldez. Credit: University of Granada

Researchers from the University of Granada have led a novel study in mice which shows that neurons mediating joint pain are different from those mediating cutaneous pain

Functional alterations in patients with arthritis negatively affect their quality of life, making daily tasks difficult, tasks that seem simple to a healthy person (such as opening a bottle, holding a cup or toothbrush, reading the newspaper or cutting a piece of bread with a knife).

This decrease in the physical function of arthritic patients can be quantified in rheumatology consultations by measuring the of the affected limb. The decrease in strength is directly proportional to both the progression of the disease and the suffered by the patient, since both are intimately related.

For the development of new analgesics it is necessary to use animal models that resemble the patient's situation as much as possible. However, despite the clinical importance of grip strength, this parameter is rarely used in preclinical research (that is, in animal experiments). However, the predominant experimental paradigm in rodent research is based on our knowledge of cutaneous pain, which occurs when the skin receives a sensory stimulus.

Scientists from the University of Granada (UGR) belonging to the Department of Pharmacology and to the Institute of Neuroscience (Biomedical Research Center of Granada) have led a study in collaboration with the pharmaceutical company Esteve and the Teófilo Hernando Institute for Drug Discovery (Spain). This study shows that grip in mice with arthritis can be used for the evaluation of analgesics, and that mediating joint pain are different from those mediating cutaneous pain. Therefore, drugs that produce analgesia in cutaneous pain do not necessarily have to produce it in joint pain.

"Further studies of this type could lead to the development of better analgesics, specifically aimed at relieving ," says Enrique J. Cobos del Moral, director of this work and researcher at the Department of Pharmacology and the Institute of Neurosciences of the University of Granada.

Explore further: Drug that strengthens analgesic effect of opioids without increasing constipation tested

More information: Ángeles Montilla-García et al. Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia, Neuropharmacology (2017). DOI: 10.1016/j.neuropharm.2017.07.029

Related Stories

Drug that strengthens analgesic effect of opioids without increasing constipation tested

March 28, 2014
Scientists from the University of Granada have taken part, alongside the Esteve laboratory, in the development of a new drug that multiplies the analgesic effect of opioids (drugs for treating intense pain), without increasing ...

New pain treatment tested in humans

November 27, 2017
Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study in the British Journal of ...

New hope for osteoarthritis patients suffering severe pain in hands

November 13, 2017
Osteoarthritis is the most prevalent arthritis worldwide and is characterised by chronic pain and impaired physical function.

Number of Americans with severe joint pain keeps rising

October 7, 2016
(HealthDay)—Severe joint pain plagues an increasing number of aging, often arthritic Americans, a new report finds.

New research reveals most pain-sensing nerves in the body specialized to respond to specific sensations

November 11, 2016
Many pain-sensing nerves in the body are thought to respond to all types of 'painful events', but new UCL research in mice reveals that in fact most are specialised to respond to specific types such as heat, cold or mechanical ...

Musculoskeletal symptoms predict psoriatic arthritis

March 13, 2017
(HealthDay)—For patients with psoriasis, nonspecific musculoskeletal symptoms, including joint pain, fatigue, and stiffness, predict the development of psoriatic arthritis (PsA), according to a study published in the March ...

Recommended for you

Marker may help target treatments for Crohn's patients

October 16, 2018
Crohn's disease (CD), a chronic inflammatory condition of the intestinal tract, has emerged as a global disease, with rates steadily increasing over the last 50 years. Experts have long suspected that CD likely represents ...

Polio: Environmental monitoring will be key as world reaches global eradication

October 15, 2018
Robust environmental monitoring should be used as the world approaches global eradication of polio, say University of Michigan researchers who recently studied the epidemiology of the 2013 silent polio outbreak in Rahat, ...

Study traces hospital-acquired bloodstream infections to patients' own bodies

October 15, 2018
The most common source of a bloodstream infection acquired during a hospital stay is not a nurse's or doctor's dirty hands, or another patient's sneeze or visitor's cough, but the patient's own gut, Stanford University School ...

Researchers make essential imaging tests safer for people at risk of acute kidney injury

October 15, 2018
Every year, millions of people undergo medical tests and procedures, such as coronary angiography, which use intravascular contrast dyes. "For the majority of patients, these are safe and necessary procedures. However, about ...

Do not give decongestants to young children for common cold symptoms, say experts

October 11, 2018
Decongestants should not be given to children under 6—and given with caution in children under 12—as there is no evidence that they alleviate symptoms such as a blocked or runny nose, and their safety is unclear, say ...

New techniques can detect Lyme disease weeks before current tests

October 11, 2018
Researchers have developed techniques to detect Lyme disease bacteria weeks sooner than current tests, allowing patients to start treatment earlier.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.