Scientists open the door to the development of better analgesics for treating joint pain

December 19, 2017, University of Granada
UGR researchers that carried out the study. From left to right: Gloria Perazzoli, Ángeles Montilla García, Enrique J Cobos del Moral, José Manuel Entrena Fernández and Miguel Ángel Tejada Giráldez. Credit: University of Granada

Researchers from the University of Granada have led a novel study in mice which shows that neurons mediating joint pain are different from those mediating cutaneous pain

Functional alterations in patients with arthritis negatively affect their quality of life, making daily tasks difficult, tasks that seem simple to a healthy person (such as opening a bottle, holding a cup or toothbrush, reading the newspaper or cutting a piece of bread with a knife).

This decrease in the physical function of arthritic patients can be quantified in rheumatology consultations by measuring the of the affected limb. The decrease in strength is directly proportional to both the progression of the disease and the suffered by the patient, since both are intimately related.

For the development of new analgesics it is necessary to use animal models that resemble the patient's situation as much as possible. However, despite the clinical importance of grip strength, this parameter is rarely used in preclinical research (that is, in animal experiments). However, the predominant experimental paradigm in rodent research is based on our knowledge of cutaneous pain, which occurs when the skin receives a sensory stimulus.

Scientists from the University of Granada (UGR) belonging to the Department of Pharmacology and to the Institute of Neuroscience (Biomedical Research Center of Granada) have led a study in collaboration with the pharmaceutical company Esteve and the Teófilo Hernando Institute for Drug Discovery (Spain). This study shows that grip in mice with arthritis can be used for the evaluation of analgesics, and that mediating joint pain are different from those mediating cutaneous pain. Therefore, drugs that produce analgesia in cutaneous pain do not necessarily have to produce it in joint pain.

"Further studies of this type could lead to the development of better analgesics, specifically aimed at relieving ," says Enrique J. Cobos del Moral, director of this work and researcher at the Department of Pharmacology and the Institute of Neurosciences of the University of Granada.

Explore further: Drug that strengthens analgesic effect of opioids without increasing constipation tested

More information: Ángeles Montilla-García et al. Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia, Neuropharmacology (2017). DOI: 10.1016/j.neuropharm.2017.07.029

Related Stories

Drug that strengthens analgesic effect of opioids without increasing constipation tested

March 28, 2014
Scientists from the University of Granada have taken part, alongside the Esteve laboratory, in the development of a new drug that multiplies the analgesic effect of opioids (drugs for treating intense pain), without increasing ...

New pain treatment tested in humans

November 27, 2017
Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study in the British Journal of ...

New hope for osteoarthritis patients suffering severe pain in hands

November 13, 2017
Osteoarthritis is the most prevalent arthritis worldwide and is characterised by chronic pain and impaired physical function.

Number of Americans with severe joint pain keeps rising

October 7, 2016
(HealthDay)—Severe joint pain plagues an increasing number of aging, often arthritic Americans, a new report finds.

New research reveals most pain-sensing nerves in the body specialized to respond to specific sensations

November 11, 2016
Many pain-sensing nerves in the body are thought to respond to all types of 'painful events', but new UCL research in mice reveals that in fact most are specialised to respond to specific types such as heat, cold or mechanical ...

Musculoskeletal symptoms predict psoriatic arthritis

March 13, 2017
(HealthDay)—For patients with psoriasis, nonspecific musculoskeletal symptoms, including joint pain, fatigue, and stiffness, predict the development of psoriatic arthritis (PsA), according to a study published in the March ...

Recommended for you

Research finds new mechanism that can cause the spread of deadly infection

April 20, 2018
Scientists at the University of Birmingham have discovered a unique mechanism that drives the spread of a deadly infection.

Selection of a pyrethroid metabolic enzyme CYP9K1 by malaria control activities

April 20, 2018
Researchers from LSTM, with partners from a number of international institutions, have shown the rapid selection of a novel P450 enzyme leading to insecticide resistance in a major malaria vector.

How environmental pollutants and genetics work together in rheumatoid arthritis

April 19, 2018
It has been known for more than three decades that individuals with a particular version of a gene—human leukocyte antigen (HLA)—have an increased risk for rheumatoid arthritis.

The bugs in your gut could make you weak in the knees

April 19, 2018
Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

Study predicts 2018 flu vaccine will have 20 percent efficacy

April 19, 2018
A Rice University study predicts that this fall's flu vaccine—a new H3N2 formulation for the first time since 2015—will likely have the same reduced efficacy against the dominant circulating strain of influenza A as the ...

Low-cost anti-hookworm drug boosts female farmers' physical fitness

April 19, 2018
Impoverished female farm workers infected with intestinal parasites known as hookworms saw significant improvements in physical fitness when they were treated with a low-cost deworming drug. The benefits were seen even in ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.