Analysis examines link between bone turnover markers and fracture risk in osteoporosis trials

January 10, 2018, Wiley

Pooled data from 14 osteoporosis clinical trials of anti-resorptive drugs indicate that patients who have reduced levels of two bone turnover markers during treatment have lower risks of later experiencing vertebral fractures.

No were significantly associated with non-vertebral or hip fracture risks, according to the Journal of Bone and Mineral Research analysis.

The findings may be helpful in the development of anti-resorptive drugs for osteoporosis, particularly in choosing the dose and treatment schedule.

Explore further: Bone loss after denosumab, only partial protection with zoledronate

More information: Journal of Bone and Mineral Research (2018). DOI: 10.1002/jbmr.3355

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