Psoriasis is independent risk factor for comorbidity in children

January 11, 2018

(HealthDay)—Children with psoriasis have an increased risk of comorbidities compared to children without psoriasis, independent of obesity, according to a study published online Jan. 10 in JAMA Dermatology.

Megha M. Tollefson, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a of 29,957 children with and an age-, sex-, and race-matched comparator cohort of 29,957 children without psoriasis. The children were divided into nonobese, without psoriasis (reference cohort); nonobese, with psoriasis; obese, without psoriasis; and obese, with psoriasis.

More children with psoriasis were obese at baseline (2.9 versus 1.5 percent). The researchers found that compared to children without psoriasis, those with psoriasis were more likely to develop each of the comorbidities. Even in those without psoriasis, obesity was a strong risk factor for development of each comorbidity (hazard ratios, 2.26 to 18.11). Nonobese children with versus without psoriasis had a risk of comorbidities that was 40 to 75 percent higher: elevated lipid levels (hazard ratio, 1.42), hypertension (hazard ratio, 1.64), diabetes (hazard ratio, 1.58), metabolic syndrome (hazard ratio, 1.62), (hazard ratio, 1.49), nonalcoholic liver disease (hazard ratio, 1.76), and elevated liver enzyme levels (hazard ratio, 1.46). Except for hypertension, there was no significant interaction between psoriasis and obesity for comorbidity risk.

"While psoriasis is a small for the development of these comorbidities, obesity is a much stronger contributor to comorbidity development in with psoriasis," the authors write.

Explore further: Prenatal exposure to maternal stress may raise psoriasis risk

More information: Abstract/Full Text

Related Stories

Prenatal exposure to maternal stress may raise psoriasis risk

December 13, 2016
(HealthDay)—Prenatal exposure to maternal bereavement is associated with psoriasis only for children born to a mother who lost a partner/spouse or an older child, according to a study published online Dec. 7 in the British ...

Psoriasis and psychiatric illnesses—what are the links?

August 11, 2017
A new review examines the potential link between psoriasis and mental health conditions.

CKD, glomerulonephritis risk higher for those with psoriasis

December 22, 2014
(HealthDay)—Psoriasis is associated with a higher risk of developing chronic kidney disease (CKD) and glomerulonephritis (GN), according to a study published online Dec. 15 in the British Journal of Dermatology.

Psoriasis impacts QoL for parents of affected children

January 23, 2017
(HealthDay)—Childhood psoriasis impacts parents' quality of life in multiple domains, especially their emotional well-being, according to a study published in the February issue of the Journal of the American Academy of ...

Psoriasis may up risk of melanoma, hematologic cancer

March 28, 2017
(HealthDay)—Patients with psoriasis may have a higher risk of melanoma and hematologic cancers than the general population, according to a study published in the April issue of the Journal of the American Academy of Dermatology.

Psoriasis patients at higher risk for arrhythmia

August 27, 2015
(HealthDay)—Patients with psoriasis are at higher risk of developing arrhythmia, even after controlling for other risk factors, according to a study published in the September issue of the Journal of the American Academy ...

Recommended for you

New long-acting approach for malaria therapy developed

January 22, 2018
A new study, published in Nature Communications, conducted by the University of Liverpool and the Johns Hopkins University School of Medicine highlights a new 'long acting' medicine for the prevention of malaria.

Virus shown to be likely cause of mystery polio-like illness

January 22, 2018
A major review by UNSW researchers has identified strong evidence that a virus called Enterovirus D68 is the cause of a mystery polio-like illness that has paralysed children in the US, Canada and Europe.

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

January 19, 2018
UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to ...

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Flu may be spread just by breathing, new study shows; coughing and sneezing not required

January 18, 2018
It is easier to spread the influenza virus (flu) than previously thought, according to a new University of Maryland-led study released today. People commonly believe that they can catch the flu by exposure to droplets from ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.