Possible link found between poor diet and back injuries

February 6, 2018

(HealthDay)—A high advanced glycation end product (H-AGE) diet is associated with decreased vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice, according to a study published recently in the Journal of Bone and Mineral Research.

Svenja Illien-Jünger, Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined whether high dietary AGE ingestion would diminish vertebral structure and function in a sex- and age-dependent manner. Female and male mice were fed low-AGE (L-AGE) or H-AGE diets for six and 18 months, and bone structure and function were measured.

The researchers observed an increase in AGE levels in serum and cortical vertebrae for 6-month-old H-AGE female mice, while for all animals, blood glucose and body weight remained normal. Six-month-old female mice had inferior vertebral trabecular structure with decreased (BMD) and bone volume fraction when fed an H-AGE diet. Six-month-old H-AGE females had functional deterioration with reduced shear and compression moduli, and maximum load to failure. H-AGE of both sexes had small but significant decreases in cortical BMD and thickness at 18 months, yet functional biomechanical behaviors were not distinguishable from other aging changes.

"We conclude that an H-AGE diet, without diabetic or overweight conditions, diminished vertebral microstructure, mechanical behaviors, and in young female mice in a manner suggesting accelerated aging," the authors write.

Explore further: Analysis examines link between bone turnover markers and fracture risk in osteoporosis trials

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Analysis examines link between bone turnover markers and fracture risk in osteoporosis trials

January 10, 2018
Pooled data from 14 osteoporosis clinical trials of anti-resorptive drugs indicate that patients who have reduced levels of two bone turnover markers during treatment have lower risks of later experiencing vertebral fractures.

New class drug significantly reduces spine fracture risk in postmenopausal women with osteoporosis

June 15, 2017
The results of a study presented today at the Annual European Congress of Rheumatology (EULAR) 2017 show that in postmenopausal women with osteoporosis, 12 months of treatment with romosozumab is associated with large, rapid ...

Which bone measures predict fractures in postmenopausal women?

January 24, 2018
When investigators compared initial bone parameters with changes in those parameters over time in postmenopausal women, they found that initial measurements were significantly associated with women's risk of fracture. Rates ...

IV bisphosphonate Tx linked to drop in bone turnover in DMD

December 6, 2015
(HealthDay)—For patients with Duchenne muscular dystrophy (DMD), intravenous bisphosphonate therapy is associated with declines in bone turnover, according to a study published online Nov. 28 in the Journal of Bone and ...

Assessment of bone density and fracture history can predict long-term fracture risk

June 21, 2017
Factors such as low bone density and previous fractures are commonly used to predict an individual's risk of experiencing a fracture over the next 10 years. A new analysis has found that a single bone density measurement ...

Intense strength training benefits postmenopausal women with low bone mass

October 4, 2017
Exercise is known to be beneficial to bone health but there is reluctance to use high intensity programs in older women with low bone mass because of the risk of fracture or other injury. A new Journal of Bone and Mineral ...

Recommended for you

Synthetic DNA-delivered antibodies protect against Ebola in preclinical studies

November 13, 2018
Scientists at The Wistar Institute and collaborators have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results, published ...

Scientists illuminate causes of hepatitis B virus-associated acute liver failure

November 13, 2018
National Institutes of Health scientists and their collaborators found that hepatitis B virus (HBV)-associated acute liver failure (ALF)—a rare condition that can turn fatal within days without liver transplantation—results ...

New strategy discovered toward possible prevention of cancers tied to mono, the 'kissing disease'

November 12, 2018
Researchers from the University of Minnesota, the Howard Hughes Medical Institute, and the University of Toronto have discovered a possible path forward in preventing the development of cancers tied to two viruses, including ...

Combination therapy promising against blindness-causing bacterial keratitis

November 12, 2018
Multidrug-resistant bacterial infections of the cornea are a leading cause of blindness and cannot be effectively managed with current ophthalmic antibiotics. A team of investigators has now devised a combination therapy ...

Hepatitis C treatment can be shortened in 50 percent of patients, study finds

November 12, 2018
Hepatitis C drugs cure more than 90 percent of patients, but can cost more than $50,000 per patient.

Salmonella found to be resistant to different classes of antibiotics

November 12, 2018
Brazil's Ministry of Health received reports of 11,524 outbreaks of foodborne diseases between 2000 and 2015, with 219,909 individuals falling sick and 167 dying from such diseases. Bacteria caused most outbreaks of such ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.