Lipoproteins, lipids have similar ties to MI, ischemic stroke

February 14, 2018

(HealthDay)—Lipoproteins and lipids are similarly associated with risk of myocardial infarction (MI) and ischemic stroke (IS) but not intracerebral hemorrhage (ICH), according to a study published in the Feb. 13 issue of the Journal of the American College of Cardiology.

Michael V. Holmes, M.D., Ph.D., from the University of Oxford in the United Kingdom, and colleagues evaluated the associations of plasma metabolic markers with risks of incident MI, IS, and ICH. Nuclear was used to measure 225 metabolic markers in baseline plasma samples as part of a nested case-control study.

Based on samples from 912 MI, 1,146 IS, and 1,138 ICH cases, as well as 1,466 common control subjects, the researchers found that very low-, intermediate-, and low-density lipoprotein particles were positively associated with MI and IS. There was an inverse association between (HDL) particles and MI apart from small HDL. No lipoprotein particles were associated with ICH. There was an inverse association between cholesterol in large HDL and MI and IS (odds ratio [OR], 0.79 and 0.88, respectively), while cholesterol in small HDL was not associated with MI and IS (OR, 0.99 and 1.06, respectively). Triglycerides within all were positively associated with MI and, similarly, IS.

"Lipoproteins and lipids showed similar associations with MI and IS, but not with ICH," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Lipid-linked genetic risk tied to abdominal aortic aneurysm

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Lipid-linked genetic risk tied to abdominal aortic aneurysm

December 5, 2017
(HealthDay)—Lipid-associated genetic risk correlates with the risk of abdominal aortic aneurysm (AAA), according to a study published online Nov. 29 in JAMA Cardiology.

Fish oil supplementation tied to lower atherothrombotic risk

April 16, 2015
(HealthDay)—Fish oil supplementation (FOS) is associated with atherothrombotic risk reduction in suspected coronary artery disease (sCAD), according to a study published in the May 1 issue of The American Journal of Cardiology.

Back to basics for heart health

February 2, 2018
As heart month kicks off, doctors at Baylor College of Medicine say the first step to taking control of your health and preventing cardiovascular disease is understanding the basics and what they represent for your heart.

High-intensity statin effect independent of lipoprotein, CRP

November 13, 2014
(HealthDay)—High-intensity statin therapy is associated with coronary atherosclerosis regression, regardless of baseline lipoprotein or C-reactive protein (CRP) levels, according to a study published in the Nov. 15 issue ...

Genetic vitamin K1 levels linked to heart disease

April 18, 2016
(HealthDay)—Genetically determined vitamin K1 is associated with coronary artery disease (CAD) and myocardial infarction (MI), according to a study published online April 8 in the Journal of Thrombosis and Haemostasis.

ApoB levels more closely tied to reduced CVD events than LDL

August 29, 2017
(HealthDay)—Clinical benefit of reduced low-density lipoprotein cholesterol (LDL-C) levels may depend on the corresponding reduction in apolipoprotein B (apoB)-containing lipoprotein particles, according to a study published ...

Recommended for you

New model suggests cuffless, non-invasive blood pressure monitoring possible using pulse waves

October 16, 2018
A large team of researchers from several institutions in China and the U.S. has developed a model that suggests it should be possible to create a cuffless, non-invasive blood pressure monitor based on measuring pulse waves. ...

Why heart contractions are weaker in those with hypertrophic cardiomyopathy

October 16, 2018
When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy (HCM). Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 ...

Novel genetic study sheds new light on risk of heart attack

October 12, 2018
Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

Researchers say ritual for orthodox Jewish men may offer heart benefits

October 11, 2018
A pilot study led by researchers at the University of Cincinnati (UC) College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

Seed oils are best for LDL cholesterol

October 9, 2018
If you want to lower your low-density lipoprotein cholesterol, called LDL or, colloquially, "bad cholesterol," the research is clear about one thing: You should exchange saturated fats with unsaturated fat. If you want to ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.