Mortality up in diabetes with low eGFR, no albuminuria

February 12, 2018

(HealthDay)—Among U.S. adults with diabetes, albumin-to-creatinine ratio (ACR) values are decreasing, but mortality rates are increasing among those with ACR <30 mg/g and low estimated glomerular filtration rates (eGFRs), according to a study published online Feb. 7 in Diabetes Care.

Holly Kramer, M.D., M.P.H., from Loyola University Chicago, and colleagues used data from the National Health and Nutrition Examination Surveys 1988 to 2006 to examine mortality trends in adults with diabetes. Via linkage with the National Death Index, mortality trends were examined by chronic kidney disease phenotype (eGFR and urine ACR level).

The researchers found that from 1988 to 2006, there was an increase in adults with an eGFR <60 mL/min/1.73 m² and an ACR <30 mg/g, from ~0.9 million (6.6 percent of the total population with diabetes during 1988 to 1994) to 2.4 million (10.1 percent of the total population with diabetes during 2007 to 2010). There was a general downward trend in for adults with diabetes and an ACR ≥30 mg/g, but an increase was seen among those with an eGFR <60 mL/min/1.73 m² and an ACR <30mg/g, from 35 to 51 deaths per 1,000 persons years during 1988-1994 to 2003-2006.

"ACR values are decreasing in U.S. adults with , but optimal management strategies are needed to reduce mortality in those with a low eGFR and an ACR <30 mg/g," the authors write.

Explore further: ACE inhibitor, statin no benefit for T1DM, high albumin excretion

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

ACE inhibitor, statin no benefit for T1DM, high albumin excretion

November 2, 2017
(HealthDay)—For adolescents with type 1 diabetes and high levels of albumin excretion, neither angiotensin-converting-enzyme (ACE) inhibitors nor statins change the albumin-to-creatinine ratio over time, according to a ...

Saxagliptin linked to improved albumin/creatinine ratios

October 25, 2016
(HealthDay)—For patients with type 2 diabetes, saxagliptin is associated with improvement in the albumin/creatinine ratio (ACR), according to a study published online Oct. 17 in Diabetes Care.

Adding albumin to risk score improves mortality prediction

October 10, 2017
(HealthDay)—Serum albumin, as a marker of frailty, can significantly improve the ability of the Society of Thoracic Surgeons (STS) and European System for Cardiac Operative Risk Evaluation (EuroSCORE-2) scores to predict ...

Early Rx with losartan doesn't slow kidney disease progression

September 16, 2016
(HealthDay)—For American-Indians with type 2 diabetes, early administration of losartan does not slow progression of glomerular filtration rate (GFR) decline, according to a study published online Sept. 9 in Diabetes Care.

Valsartan cuts microalbuminuria in impaired glucose tolerance

February 9, 2017
(HealthDay)—For patients with impaired glucose tolerance (IGT), valsartan is associated with reduced incidence of microalbuminuria, according to a study published online Jan. 17 in Diabetes, Obesity and Metabolism.

Reduced eGFR, increased UACR linked to incident A-fib

August 11, 2017
(HealthDay)—Reduced estimated glomerular filtration rate (eGFR) and elevated urine albumin-to-creatinine ratio (UACR) are associated with increased risk of incident atrial fibrillation (AF), according to research published ...

Recommended for you

Deep brain stimulation found to improve diabetes symptoms

May 24, 2018
A team of researchers from several institutions in the Netherlands and Yale University in the U.S. has found evidence that suggests deep brain stimulation (DBS) can help treat type 2 diabetes. In their paper published in ...

Women with pregnancy-related diabetes may be at risk for chronic kidney disease

May 21, 2018
Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the National Institutes of Health and other institutions. The study appears ...

Diabetes researchers find switch for fatty liver disease

May 17, 2018
Duke researchers have identified a key fork in the road for the way the liver deals with carbohydrates, fats and protein. They say it could be a promising new target for combating the pandemics of fatty liver disease and ...

New study of youth with type 1 diabetes connects 'honeymoon period' with lower LDL cholesterol

May 17, 2018
A new study by UMass Medical School physician-scientist Benjamin U. Nwosu, MD, finds that children with type 1 diabetes who experienced a partial clinical remission, or "honeymoon phase," had significantly lower low-density ...

"Living drug factories" may one day replace injections

May 17, 2018
Patients with diabetes generally rely on constant injections of insulin to control their disease. But MIT spinout Sigilon Therapeutics is developing an implantable, insulin-producing device that may one day make injections ...

Boosting the effects of vitamin D to tackle diabetes

May 10, 2018
More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.